Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 14/20 | 0.59 |
| ▸ | FYN | P06241 | 1/20 | 0.55 |
| ▸ | PTK2 | Q05397 | 11/20 | 0.54 |
| ▸ | JAK3 | P52333 | 10/20 | 0.54 |
| ▸ | SRC | P12931 | 1/20 | 0.48 |
| ▸ | JAK1 | P23458 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13535990 | 0.85 | JAK2 (0.58) | JAK2PTK2JAK3SRCJAK1 | |
| SCHEMBL13535774 | 0.84 | JAK2 (0.56) | JAK2PTK2JAK3JAK1 | |
| SCHEMBL3231807 | 0.83 | JAK2 (0.80) | JAK2PTK2JAK3 | |
| SCHEMBL13536022 | 0.82 | JAK2 (0.58) | JAK2PTK2JAK3JAK1 | |
| SCHEMBL13535741 | 0.81 | JAK2 (0.57) | JAK2PTK2JAK3JAK1 | |
| SCHEMBL3230871 | 0.81 | JAK2 (0.60) | JAK2PTK2JAK3JAK1 | |
| SCHEMBL13535602 | 0.79 | JAK2 (0.55) | JAK2PTK2JAK3JAK1 | |
| SCHEMBL20941 | 0.78 | FYN (0.51) | JAK2FYNPTK2JAK3SRC | |
| SCHEMBL1499415 | 0.78 | FYN (0.62) | FYNSRC | |
| SCHEMBL13536161 | 0.77 | JAK2 (0.66) | JAK2PTK2JAK3JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010010184-A1 | [1, 2, 4] TRIAZOLO [1, 5-A] PYRIDINES AS JAK INHIBITORS | GALAPAGOS NV (BE) | 2010-01-28 | — | — | WO | disclosed |