Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 16/20 | 0.69 |
| ▸ | JAK3 | P52333 | 9/20 | 0.69 |
| ▸ | PTK2 | Q05397 | 9/20 | 0.69 |
| ▸ | JAK1 | P23458 | 10/20 | 0.58 |
| ▸ | AXL | P30530 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13536086 | 0.92 | JAK2 (0.57) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL13536002 | 0.91 | JAK2 (0.68) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL13535923 | 0.91 | JAK2 (0.63) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL13535649 | 0.91 | JAK2 (0.56) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL13535812 | 0.91 | JAK2 (0.56) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL13536035 | 0.90 | JAK2 (0.68) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL13535690 | 0.90 | JAK2 (0.55) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL13535865 | 0.89 | JAK2 (0.54) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL13536166 | 0.89 | JAK1 (0.65) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL13535744 | 0.88 | JAK2 (0.53) | JAK2JAK3PTK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010010184-A1 | [1, 2, 4] TRIAZOLO [1, 5-A] PYRIDINES AS JAK INHIBITORS | GALAPAGOS NV (BE) | 2010-01-28 | — | — | WO | disclosed |