Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 16/20 | 0.56 |
| ▸ | JAK3 | P52333 | 13/20 | 0.54 |
| ▸ | PTK2 | Q05397 | 13/20 | 0.54 |
| ▸ | JAK1 | P23458 | 3/20 | 0.52 |
| ▸ | TTK | P33981 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13535997 | 0.91 | JAK2 (0.54) | JAK2JAK3PTK2TTK | |
| SCHEMBL13535584 | 0.80 | JAK2 (0.69) | JAK2JAK3PTK2 | |
| SCHEMBL13535999 | 0.80 | JAK2 (0.62) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL13535620 | 0.79 | JAK2 (0.74) | JAK2JAK3PTK2 | |
| SCHEMBL13535609 | 0.78 | JAK2 (0.67) | JAK2JAK3PTK2 | |
| SCHEMBL13535985 | 0.78 | JAK2 (0.58) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL13535590 | 0.78 | JAK2 (0.59) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL13535750 | 0.77 | JAK2 (0.66) | JAK2JAK3PTK2 | |
| SCHEMBL13536158 | 0.77 | JAK2 (0.52) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL13535740 | 0.76 | JAK2 (0.54) | JAK2JAK3PTK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010010184-A1 | [1, 2, 4] TRIAZOLO [1, 5-A] PYRIDINES AS JAK INHIBITORS | GALAPAGOS NV (BE) | 2010-01-28 | — | — | WO | disclosed |