Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 16/20 | 0.48 |
| ▸ | JAK3 | P52333 | 3/20 | 0.48 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.48 |
| ▸ | JAK1 | P23458 | 15/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13536102 | 1.00 | JAK2 (0.48) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL13536101 | 0.91 | JAK2 (0.52) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL13535746 | 0.86 | JAK2 (0.53) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL13536111 | 0.85 | JAK2 (0.55) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL13535789 | 0.85 | JAK2 (0.50) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL13536109 | 0.84 | JAK2 (0.52) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL13536098 | 0.80 | JAK2 (0.53) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL13535670 | 0.80 | JAK2 (0.53) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL13536100 | 0.80 | JAK2 (0.53) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL13536056 | 0.78 | JAK2 (0.51) | JAK2JAK3PTK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010010184-A1 | [1, 2, 4] TRIAZOLO [1, 5-A] PYRIDINES AS JAK INHIBITORS | GALAPAGOS NV (BE) | 2010-01-28 | — | — | WO | disclosed |