Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCQ | Q04759 | 12/20 | 0.48 |
| ▸ | PRKCA | P17252 | 11/20 | 0.48 |
| ▸ | PTPN11 | Q06124 | 8/20 | 0.44 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.43 |
| ▸ | PRKCG | P05129 | 1/20 | 0.42 |
| ▸ | PRKCB | P05771 | 1/20 | 0.42 |
| ▸ | JMJD7 | P0C870 | 1/20 | 0.42 |
| ▸ | PRKCH | P24723 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9882391 | 0.90 | PTPN11 (0.45) | PRKCQPRKCAPTPN11PRKCDKCNH2 | |
| SCHEMBL9882261 | 0.89 | PIM1 (0.48) | PRKCQPRKCAPTPN11PRKCDPRKCG | |
| SCHEMBL9882341 | 0.88 | PRKCQ (0.40) | PRKCQPRKCAPTPN11PRKCDPRKCG | |
| SCHEMBL9882324 | 0.87 | PIM1 (0.49) | PRKCQPRKCAPRKCDPRKCGPRKCB | |
| SCHEMBL15273796 | 0.86 | PRKCQ (0.44) | PRKCQPRKCAPTPN11PRKCD | |
| SCHEMBL9881935 | 0.85 | PRKCQ (0.53) | PRKCQPRKCAPRKCD | |
| SCHEMBL9882073 | 0.84 | PRKCQ (0.48) | PRKCQPRKCAPRKCDGSK3B | |
| SCHEMBL9882394 | 0.84 | PRKCQ (0.42) | PRKCQPRKCAPTPN11PRKCDPRKCB | |
| SCHEMBL9882252 | 0.83 | PRKCQ (0.40) | PRKCQPRKCAPRKCDPRKCGPRKCB | |
| SCHEMBL9882024 | 0.83 | PRKCQ (0.44) | PRKCQPRKCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010011772-A2 | TRI-CYCLIC PYRAZOLOPYRIDINE KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-01-28 | — | — | WO | disclosed |