Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 14/20 | 0.80 |
| ▸ | PIM3 | Q86V86 | 14/20 | 0.80 |
| ▸ | PIM2 | Q9P1W9 | 14/20 | 0.80 |
| ▸ | TTR | P02766 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | NAT1 | P18440 | 1/20 | 0.58 |
| ▸ | IGF1R | P08069 | 1/20 | 0.58 |
| ▸ | GSK3B | P49841 | 1/20 | 0.55 |
| ▸ | STK17B | O94768 | 2/20 | 0.54 |
| ▸ | BCL2 | P10415 | 2/20 | 0.54 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.54 |
| ▸ | CDK7 | P50613 | 2/20 | 0.54 |
| ▸ | DAPK1 | P53355 | 2/20 | 0.54 |
| ▸ | CAMK4 | Q16566 | 2/20 | 0.54 |
| ▸ | MAPK15 | Q8TD08 | 2/20 | 0.54 |
| ▸ | PNPLA2 | Q96AD5 | 2/20 | 0.54 |
| ▸ | HIPK3 | Q9H422 | 2/20 | 0.54 |
| ▸ | TDP2 | O95551 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12284109 | 0.90 | PIM1 (0.90) | PIM1PIM3PIM2TTRMEN1 | |
| SCHEMBL1580360 | 0.89 | PIM2 (1.00) | PIM1PIM3PIM2TTRMEN1 | |
| SCHEMBL1580364 | 0.89 | PIM2 (1.00) | PIM1PIM3PIM2TTRMEN1 | |
| Hydrochloric Acid SCHEMBL2423491 | 0.89 | PIM1 (0.88) | PIM1PIM3PIM2TTRMEN1 | |
| Hydrochloric Acid SCHEMBL2423494 | 0.89 | PIM1 (0.88) | PIM1PIM3PIM2TTRMEN1 | |
| SCHEMBL5606599 | 0.88 | PIM2 (0.74) | PIM1PIM3PIM2TTRMEN1 | |
| SCHEMBL2421824 | 0.88 | PIM1 (0.74) | PIM1PIM3PIM2TTRMEN1 | |
| Hydrochloric Acid SCHEMBL2427427 | 0.88 | PIM2 (0.97) | PIM1PIM3PIM2TTRMEN1 | |
| SCHEMBL1579117 | 0.88 | PIM2 (0.74) | PIM1PIM3PIM2TTRMEN1 | |
| Hydrochloric Acid SCHEMBL2427429 | 0.88 | PIM2 (0.97) | PIM1PIM3PIM2TTRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010001169-A2 | CHEMICAL COMPOUNDS 251 | ASTRAZENECA AB (SE) | 2010-01-07 | — | — | WO | disclosed |