Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | PIM2 | Q9P1W9 | 7/20 | 0.43 |
| ▸ | PIM1 | P11309 | 6/20 | 0.42 |
| ▸ | PIM3 | Q86V86 | 6/20 | 0.42 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | IGF1R | P08069 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | ESRRA | P11474 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1580671 | 0.93 | PIM2 (0.44) | MAPTMEN1NPC1PKMRAB9A | |
| SCHEMBL1580670 | 0.93 | PIM2 (0.44) | MAPTMEN1NPC1PKMRAB9A | |
| SCHEMBL12282079 | 0.93 | PIM2 (0.44) | MAPTMEN1NPC1PKMRAB9A | |
| SCHEMBL1580902 | 0.84 | PIM2 (0.46) | PIM2PIM1PIM3NR1H4HPGD | |
| SCHEMBL1580903 | 0.84 | PIM2 (0.46) | PIM2PIM1PIM3NR1H4HPGD | |
| SCHEMBL12282081 | 0.84 | PIM2 (0.46) | PIM2PIM1PIM3NR1H4HPGD | |
| SCHEMBL12281659 | 0.84 | PIM2 (0.46) | PIM2PIM1PIM3NR1H4HPGD | |
| SCHEMBL2418589 | 0.84 | PIM2 (0.46) | PIM2PIM1PIM3NR1H4HPGD | |
| SCHEMBL2418591 | 0.84 | PIM2 (0.46) | PIM2PIM1PIM3NR1H4HPGD | |
| SCHEMBL1579112 | 0.83 | MAPT (0.51) | MAPTMEN1NPC1PKMRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010001169-A2 | CHEMICAL COMPOUNDS 251 | ASTRAZENECA AB (SE) | 2010-01-07 | — | — | WO | disclosed |