Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 6/20 | 0.72 |
| ▸ | PIM3 | Q86V86 | 6/20 | 0.72 |
| ▸ | PIM2 | Q9P1W9 | 6/20 | 0.72 |
| ▸ | GSK3B | P49841 | 3/20 | 0.45 |
| ▸ | CDC7 | O00311 | 1/20 | 0.45 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.45 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.45 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.45 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.45 |
| ▸ | CLK2 | P49760 | 1/20 | 0.45 |
| ▸ | GSK3A | P49840 | 1/20 | 0.45 |
| ▸ | NEK4 | P51957 | 1/20 | 0.45 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.45 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.45 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.45 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.45 |
| ▸ | HIPK4 | Q8NE63 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2420536 | 0.94 | PIM1 (0.75) | PIM1PIM3PIM2PTPN1KDM4D | |
| SCHEMBL12282566 | 0.94 | PIM1 (0.75) | PIM1PIM3PIM2PTPN1KDM4D | |
| SCHEMBL2420531 | 0.94 | PIM1 (0.75) | PIM1PIM3PIM2PTPN1KDM4D | |
| SCHEMBL2423398 | 0.94 | PIM1 (0.75) | PIM1PIM3PIM2PTPN1KDM4D | |
| SCHEMBL2420533 | 0.94 | PIM1 (0.75) | PIM1PIM3PIM2PTPN1KDM4D | |
| SCHEMBL2420529 | 0.94 | PIM1 (0.75) | PIM1PIM3PIM2PTPN1KDM4D | |
| SCHEMBL2423404 | 0.94 | PIM1 (0.75) | PIM1PIM3PIM2PTPN1KDM4D | |
| SCHEMBL2423456 | 0.84 | PIM1 (0.60) | PIM1PIM3PIM2GSK3BCDC7 | |
| SCHEMBL2423461 | 0.84 | PIM1 (0.60) | PIM1PIM3PIM2GSK3BCDC7 | |
| SCHEMBL2423457 | 0.84 | PIM1 (0.60) | PIM1PIM3PIM2GSK3BCDC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010001169-A2 | CHEMICAL COMPOUNDS 251 | ASTRAZENECA AB (SE) | 2010-01-07 | — | — | WO | disclosed |