Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 4/20 | 0.48 |
| ▸ | CDK1 | P06493 | 2/20 | 0.48 |
| ▸ | PLK4 | O00444 | 1/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.48 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.48 |
| ▸ | PRKCG | P05129 | 1/20 | 0.48 |
| ▸ | INSR | P06213 | 1/20 | 0.48 |
| ▸ | FES | P07332 | 1/20 | 0.48 |
| ▸ | IGF1R | P08069 | 1/20 | 0.48 |
| ▸ | ROS1 | P08922 | 1/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.48 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.48 |
| ▸ | FER | P16591 | 1/20 | 0.48 |
| ▸ | FLT1 | P17948 | 1/20 | 0.48 |
| ▸ | MARK3 | P27448 | 1/20 | 0.48 |
| ▸ | FLT4 | P35916 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1516690 | 0.82 | PDPK1 (0.57) | CDK2CDK1PLK4AURKAJAK2 | |
| Bromide SCHEMBL1516571 | 0.81 | PDPK1 (0.56) | CDK2CDK1PLK4AURKAJAK2 | |
| SCHEMBL1801591 | 0.81 | PDPK1 (0.53) | CDK2CDK1PLK4AURKAJAK2 | |
| SCHEMBL13539023 | 0.79 | ROCK1 (0.39) | CDK2JAK2PRKCGFLT3IRAK1 | |
| SCHEMBL1799923 | 0.79 | DYRK1A (0.50) | CDK2CDK1PLK4AURKAJAK2 | |
| SCHEMBL13539068 | 0.78 | PDPK1 (0.39) | CDK2JAK2PRKCGFLT3IRAK1 | |
| SCHEMBL9279751 | 0.75 | JAK2 (0.55) | CDK2CDK1PLK4AURKAJAK2 | |
| SCHEMBL1800868 | 0.75 | PDPK1 (0.53) | CDK2CDK1PLK4AURKAJAK2 | |
| SCHEMBL13505098 | 0.74 | MAP4K4 (0.44) | CDK2CDK1PLK4AURKAJAK2 | |
| SCHEMBL13888049 | 0.74 | ROCK1 (0.55) | CDK2CDK1PLK4AURKAJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7645769-B2 | Inhibitors of c-Jun N-terminal kinases for the treatment of neurodegenerative disorders relating to apoptosis and/or inflammation | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2010-01-12 | — | — | US | disclosed |