Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 6/20 | 0.43 |
| ▸ | HSP90AB1 | P08238 | 6/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 9/20 | 0.41 |
| ▸ | ADORA2B | P29275 | 9/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 9/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 8/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PDE8B | O95263 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14567907 | 0.78 | HSP90AB1 (0.54) | HSP90AA1HSP90AB1ADORA2AADORA2BADORA1 | |
| SCHEMBL14567912 | 0.77 | HSP90AA1 (0.48) | HSP90AA1HSP90AB1ADORA2AADORA2BADORA1 | |
| SCHEMBL14568315 | 0.75 | HSP90AA1 (0.68) | HSP90AA1HSP90AB1ADORA2AADORA2BADORA1 | |
| SCHEMBL13322067 | 0.75 | ADORA2A (0.56) | ADORA2AADORA2BADORA1ADORA3 | |
| SCHEMBL14506532 | 0.74 | HSP90AA1 (0.57) | HSP90AA1HSP90AB1 | |
| SCHEMBL14568318 | 0.74 | HSP90AB1 (0.49) | HSP90AA1HSP90AB1ADORA2AADORA2BADORA1 | |
| SCHEMBL14568314 | 0.73 | HSP90AA1 (0.57) | HSP90AA1HSP90AB1ADORA2AADORA2BADORA1 | |
| SCHEMBL14567909 | 0.71 | HSP90AA1 (0.50) | HSP90AA1HSP90AB1ADORA2AADORA2BADORA1 | |
| SCHEMBL13539951 | 0.71 | ADORA2A (0.42) | HSP90AA1HSP90AB1ADORA2AADORA1 | |
| SCHEMBL14568076 | 0.70 | HSP90AA1 (0.55) | HSP90AA1HSP90AB1ADORA2AADORA2BADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2145888-A1 | Deazapurine derivatives as HSP90-Inhibitors | Conforma Therapeutics Corporation (US) | 2010-01-20 | — | — | EP | disclosed |