Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 10/20 | 0.41 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.39 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.39 |
| ▸ | CKS1B | P61024 | 1/20 | 0.38 |
| ▸ | SKP1 | P63208 | 1/20 | 0.38 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | HPGDS | O60760 | 1/20 | 0.35 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.35 |
| ▸ | KIT | P10721 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 2/20 | 0.35 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.35 |
| ▸ | GPR6 | P46095 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8275982 | 0.91 | NAMPT (0.41) | NAMPTDPP8DPP9CKS1BSKP1 | |
| SCHEMBL8217661 | 0.89 | CHRM4 (0.43) | NAMPTDPP8DPP9CKS1BSKP1 | |
| SCHEMBL8223431 | 0.88 | CHRM4 (0.42) | NAMPTDPP8DPP9CKS1BSKP1 | |
| SCHEMBL8223423 | 0.81 | NAMPT (0.42) | NAMPTDPP8DPP9KCNH2 | |
| SCHEMBL8273733 | 0.78 | NAMPT (0.43) | NAMPT | |
| SCHEMBL13542844 | 0.78 | NAMPT (0.44) | NAMPTDPP8DPP9KCNH2SSTR4 | |
| SCHEMBL8275981 | 0.77 | NAMPT (0.42) | NAMPTDPP8DPP9F10 | |
| SCHEMBL8224777 | 0.75 | NAMPT (0.42) | NAMPT | |
| SCHEMBL8221929 | 0.75 | CHRM4 (0.44) | NAMPTDPP8DPP9SSTR4 | |
| SCHEMBL12216389 | 0.74 | NAMPT (0.41) | NAMPTKCNH2CSF1RF10SCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7652020-B2 | novel hydantoin derivatives to inhibit matrix metalloproteinases (MMPs), a disintegrin and metalloproteases (ADAMs) and/or tumor necrosis factor alpha converting enzyme (TACE) and in so doing prevent the release of tumor necrosis factor alpha (TNF- alpha ); autoimmune diseases; side effect reduction | SCHERING CORPORATION (US) | 2010-01-26 | — | — | US | disclosed |
| US-7652020-B2 | novel hydantoin derivatives to inhibit matrix metalloproteinases (MMPs), a disintegrin and metalloproteases (ADAMs) and/or tumor necrosis factor alpha converting enzyme (TACE) and in so doing prevent the release of tumor necrosis factor alpha (TNF- alpha ); autoimmune diseases; side effect reduction | SCHERING CORPORATION (US) | 2010-01-26 | — | — | US | disclosed |