Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 11/20 | 0.53 |
| ▸ | FLT1 | P17948 | 10/20 | 0.53 |
| ▸ | KDR | P35968 | 1/20 | 0.53 |
| ▸ | ABL1 | P00519 | 13/20 | 0.51 |
| ▸ | BCR | P11274 | 4/20 | 0.44 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3534487 | 0.88 | FGFR1 (0.65) | FGFR1FLT1KDRABL1BCR | |
| SCHEMBL5866881 | 0.88 | FGFR1 (0.67) | FGFR1FLT1KDRABL1BCR | |
| SCHEMBL3536436 | 0.88 | FGFR1 (0.57) | FGFR1FLT1KDRABL1BCR | |
| SCHEMBL3539570 | 0.88 | FGFR1 (0.66) | FGFR1FLT1KDRABL1BCR | |
| SCHEMBL3539015 | 0.85 | FGFR1 (0.55) | FGFR1FLT1KDRABL1BCR | |
| SCHEMBL3537562 | 0.84 | FGFR1 (0.61) | FGFR1FLT1KDRABL1BCR | |
| SCHEMBL3536381 | 0.83 | FGFR1 (0.57) | FGFR1FLT1KDRABL1BCR | |
| SCHEMBL3539963 | 0.83 | FGFR1 (0.49) | FGFR1FLT1KDRABL1PDPK1 | |
| SCHEMBL5866856 | 0.82 | ABL1 (0.66) | FGFR1FLT1KDRABL1BCR | |
| SCHEMBL3539063 | 0.81 | ABL1 (0.58) | FGFR1FLT1KDRABL1BCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7642278-B2 | Nitrogen compounds such as 3-(5-morpholin-4-yl-1H-benz-imidazol-2-yl)-1H-indazole and/or isomers, used as immunology modulators, antidiabetic agents, antiogenesis inhibitors or for prophylaxis of Alzheimer's disease | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2010-01-05 | — | — | US | disclosed |
| US-7642278-B2 | Nitrogen compounds such as 3-(5-morpholin-4-yl-1H-benz-imidazol-2-yl)-1H-indazole and/or isomers, used as immunology modulators, antidiabetic agents, antiogenesis inhibitors or for prophylaxis of Alzheimer's disease | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2010-01-05 | — | — | US | disclosed |