Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WEE1 | P30291 | 3/20 | 0.54 |
| ▸ | FGFR1 | P11362 | 8/20 | 0.51 |
| ▸ | EGFR | P00533 | 3/20 | 0.51 |
| ▸ | PKN1 | Q16512 | 3/20 | 0.49 |
| ▸ | PAK4 | O96013 | 2/20 | 0.49 |
| ▸ | PAK1 | Q13153 | 3/20 | 0.48 |
| ▸ | SRC | P12931 | 5/20 | 0.47 |
| ▸ | ABL1 | P00519 | 3/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.47 |
| ▸ | KIT | P10721 | 1/20 | 0.47 |
| ▸ | PAK3 | O75914 | 2/20 | 0.43 |
| ▸ | PAK2 | Q13177 | 2/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.42 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.42 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14681982 | 0.91 | WEE1 (0.47) | WEE1FGFR1PKN1PAK4SRC | |
| SCHEMBL15787829 | 0.85 | PKN1 (0.56) | WEE1FGFR1EGFRPKN1PAK4 | |
| SCHEMBL13553495 | 0.79 | PKN1 (0.51) | WEE1FGFR1EGFRPKN1PAK4 | |
| SCHEMBL14682007 | 0.79 | PAK1 (0.52) | WEE1FGFR1EGFRPKN1PAK4 | |
| SCHEMBL15787974 | 0.78 | WEE1 (0.57) | WEE1FGFR1EGFRPKN1PAK4 | |
| SCHEMBL13553533 | 0.78 | PKN1 (0.66) | WEE1FGFR1EGFRPKN1PAK4 | |
| SCHEMBL14682082 | 0.76 | JAK3 (0.47) | FGFR1PKN1PAK4SRCJAK3 | |
| SCHEMBL15787987 | 0.74 | PKN1 (0.51) | WEE1FGFR1EGFRPKN1PAK4 | |
| SCHEMBL13553685 | 0.74 | PAK1 (0.51) | WEE1FGFR1EGFRPKN1PAK4 | |
| SCHEMBL13553531 | 0.74 | PKN1 (0.76) | WEE1FGFR1EGFRPKN1PAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8372970-B2 | 8-ethyl-6-(aryl)pyrido[2,3-D]pyrimidin-7(8H)-ones for the treatment of CNS disorders | AFRAXIS, INC. (US) | 2013-02-12 | — | — | US | disclosed |
| US-20120270866-A1 | 8-ETHYL-6-(ARYL)PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONES FOR THE TREATMENT OF CNS DISORDERS | AFRAXIS INC. (US) | 2012-10-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120270866-A1 | 8-ETHYL-6-(ARYL)PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONES FOR THE TREATMENT OF CNS DISORDERS | PAK2, PAK6, PAK5 | WEE1 850/4885FGFR1 2256/4885EGFR 2012/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.