Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CRHBP | P24387 | 2/20 | 0.32 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.32 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
| ▸ | JAK1 | P23458 | 1/20 | 0.30 |
| ▸ | JAK3 | P52333 | 1/20 | 0.30 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17090455 | 1.00 | KDM4E (0.36) | KDM4ELMNAKMT2AL3MBTL1CRHBP | |
| SCHEMBL13113663 | 0.92 | KDM4E (0.37) | KDM4ELMNAKMT2AL3MBTL1CRHBP | |
| SCHEMBL13105264 | 0.92 | KDM4E (0.37) | KDM4ELMNAKMT2AL3MBTL1CRHBP | |
| SCHEMBL17090554 | 0.91 | KDM4E (0.40) | KDM4ELMNAKMT2AL3MBTL1CRHBP | |
| SCHEMBL13566082 | 0.91 | KDM4E (0.40) | KDM4ELMNAKMT2AL3MBTL1CRHBP | |
| SCHEMBL17090454 | 0.89 | KDM4E (0.35) | KDM4ELMNAKMT2AL3MBTL1CRHBP | |
| SCHEMBL13565281 | 0.89 | KDM4E (0.35) | KDM4ELMNAKMT2AL3MBTL1CRHBP | |
| SCHEMBL11936079 | 0.87 | KDM4E (0.36) | KDM4ELMNAKMT2AL3MBTL1CRHBP | |
| SCHEMBL11940826 | 0.87 | KDM4E (0.36) | KDM4ELMNAKMT2AL3MBTL1CRHBP | |
| SCHEMBL17090447 | 0.86 | KMT2A (0.38) | KDM4ELMNAKMT2AL3MBTL1CRHBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8299265-B2 | Amine derivatives having NPY Y5 receptor antagonistic activity and the uses thereof | SHIONOGI & CO., LTD. (JP) | 2012-10-30 | — | — | US | disclosed |