Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.67 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 2/20 | 0.35 |
| ▸ | DRD3 | P35462 | 2/20 | 0.35 |
| ▸ | SLC2A1 | P11166 | 5/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | NPY5R | Q15761 | 3/20 | 0.33 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.33 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | IGF1R | P08069 | 1/20 | 0.32 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13565506 | 0.88 | MAPT (0.66) | MAPTTLR7KMT2ASLC2A1KCNH2 | |
| SCHEMBL10113543 | 0.86 | MAPT (0.61) | MAPTTLR7DRD2DRD3GAA | |
| SCHEMBL11934977 | 0.83 | MAPT (0.60) | MAPTTLR7KMT2AADORA2AADORA1 | |
| SCHEMBL13564759 | 0.78 | MAPT (0.58) | MAPTTLR7KMT2ADRD2DRD3 | |
| SCHEMBL17090301 | 0.78 | MAPT (0.58) | MAPTTLR7KMT2ADRD2DRD3 | |
| SCHEMBL10133723 | 0.78 | MAPT (0.68) | MAPTTLR7KMT2ADRD2DRD3 | |
| SCHEMBL13940133 | 0.77 | MAPT (0.72) | MAPTTLR7KMT2AADORA2AADORA1 | |
| SCHEMBL10113816 | 0.75 | MAPT (0.60) | MAPTTLR7DRD2DRD3ADORA2A | |
| SCHEMBL13203787 | 0.74 | MAPT (0.57) | MAPTDRD2DRD3NPY5R | |
| SCHEMBL10133713 | 0.74 | MAPT (0.57) | MAPTDRD2DRD3NPY5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9139518-B2 | Amine derivative having NPY Y5 receptor antagonistic activity | SHIONOGI & CO., LTD. (JP) | 2015-09-22 | — | — | US | disclosed |
| US-8299265-B2 | Amine derivatives having NPY Y5 receptor antagonistic activity and the uses thereof | SHIONOGI & CO., LTD. (JP) | 2012-10-30 | — | — | US | disclosed |