Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.59 |
| ▸ | GAA | P10253 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.49 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.49 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.49 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.49 |
| ▸ | CYP8B1 | Q9UNU6 | 1/20 | 0.49 |
| ▸ | DGAT1 | O75907 | 5/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20194400 | 1.00 | MAPT (0.76) | MAPTALDH1A1SMN1; SMN2GAAKDM4E | |
| SCHEMBL26212871 | 1.00 | MAPT (0.76) | MAPTALDH1A1SMN1; SMN2GAAKDM4E | |
| SCHEMBL12067678 | 0.88 | MAPT (0.77) | MAPTALDH1A1SMN1; SMN2GAAKDM4E | |
| SCHEMBL12315830 | 0.88 | MAPT (0.63) | MAPTALDH1A1SMN1; SMN2GAAKDM4E | |
| SCHEMBL20639674 | 0.87 | MAPT (0.61) | MAPTALDH1A1SMN1; SMN2GAAKDM4E | |
| SCHEMBL9284781 | 0.86 | MAPT (1.00) | MAPTALDH1A1SMN1; SMN2GAAKDM4E | |
| SCHEMBL3120176 | 0.86 | MAPT (1.00) | MAPTALDH1A1SMN1; SMN2GAAKDM4E | |
| SCHEMBL2548018 | 0.86 | MAPT (1.00) | MAPTALDH1A1SMN1; SMN2GAAKDM4E | |
| SCHEMBL6750794 | 0.86 | MAPT (0.71) | MAPTALDH1A1SMN1; SMN2GAAKDM4E | |
| SCHEMBL6750795 | 0.86 | MAPT (0.71) | MAPTALDH1A1SMN1; SMN2GAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7625898-B2 | Posaconazole polymer conjugates and methods of treatment using posaconazole and polymer conjugates thereof | ENZON PHARMACEUTICALS, INC. (US) | 2009-12-01 | — | — | US | disclosed |