Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 1/20 | 0.58 |
| ▸ | ALB | P02768 | 1/20 | 0.58 |
| ▸ | MAOA | P21397 | 1/20 | 0.58 |
| ▸ | CNR1 | P21554 | 1/20 | 0.58 |
| ▸ | DRD1 | P21728 | 1/20 | 0.58 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.58 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.58 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.58 |
| ▸ | BCL2 | P10415 | 1/20 | 0.56 |
| ▸ | VSIR | Q9H7M9 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 6/20 | 0.50 |
| ▸ | NPC1 | O15118 | 5/20 | 0.50 |
| ▸ | RAB9A | P51151 | 5/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | HPSE | Q9Y251 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1675377 | 0.86 | TTR (0.68) | TTRALBMAOACNR1DRD1 | |
| SCHEMBL25732562 | 0.84 | TTR (0.60) | TTRALBMAOACNR1DRD1 | |
| SCHEMBL31261528 | 0.84 | TTR (0.62) | TTRALBMAOACNR1DRD1 | |
| SCHEMBL29784233 | 0.83 | TTR (0.72) | TTRALBMAOACNR1DRD1 | |
| SCHEMBL121966 | 0.83 | TTR (0.72) | TTRALBMAOACNR1DRD1 | |
| SCHEMBL20897632 | 0.81 | TTR (0.78) | TTRALBMAOACNR1DRD1 | |
| SCHEMBL3956805 | 0.81 | NPC1 (0.64) | TTRALBMAOACNR1DRD1 | |
| SCHEMBL22442342 | 0.81 | TTR (0.62) | TTRALBMAOACNR1DRD1 | |
| SCHEMBL1675462 | 0.81 | NPC1 (0.63) | TTRALBMAOACNR1DRD1 | |
| SCHEMBL1675290 | 0.80 | TTR (0.68) | TTRALBMAOACNR1DRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009151546-A2 | METHODS FOR TREATING SPINAL MUSCULAR ATROPHY | PTC THERAPEUTICS, INC. (US) | 2009-12-17 | — | — | WO | disclosed |