Tyrosine

Tyrosine

SCHEMBL1356958

COC.N[C@@H](Cc1ccc(O)cc1)C(=O)O

nearest known ligand 0.86

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC7A5 Q01650 5/20 0.86
PTGS1 P23219 2/20 0.61
ALPI P09923 1/20 0.61
PKM P14618 1/20 0.61
XIAP P98170 1/20 0.61
KDM4E B2RXH2 1/20 0.57
USP2 O75604 1/20 0.57
EGFR P00533 1/20 0.57
LCK P06239 1/20 0.57
FYN P06241 1/20 0.57
ADORA3 P0DMS8 1/20 0.57
ALOX15 P16050 1/20 0.57
HTR2A P28223 1/20 0.57
PTGS2 P35354 1/20 0.57
RECQL P46063 1/20 0.57
HIF1A Q16665 1/20 0.57
HSD17B10 Q99714 1/20 0.57
TDP1 Q9NUW8 1/20 0.57
PCNA P12004 1/20 0.55
TAAR1 Q96RJ0 3/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tyrosine SCHEMBL1356957 1.00 SLC7A5 (0.86) SLC7A5PTGS1ALPIPKMXIAP
Tyrosine SCHEMBL7413965 0.97 SLC7A5 (0.80) SLC7A5PTGS1ALPIPKMXIAP
Tyrosine SCHEMBL22390812 0.95 SLC7A5 (0.77) SLC7A5PTGS1ALPIPKMXIAP
Tyrosine SCHEMBL28297995 0.93 SLC7A5 (0.92) SLC7A5PTGS1ALPIPKMXIAP
Tyrosine SCHEMBL5222909 0.93 SLC7A5 (0.92) SLC7A5PTGS1ALPIPKMXIAP
Tyrosine SCHEMBL28270669 0.93 SLC7A5 (0.92) SLC7A5PTGS1ALPIPKMXIAP
Tyrosine SCHEMBL6374042 0.93 SLC7A5 (0.92) SLC7A5PTGS1ALPIPKMXIAP
Tyrosine SCHEMBL10978820 0.93 SLC7A5 (1.00) SLC7A5PTGS1ALPIPKMXIAP
Tyrosine SCHEMBL11676395 0.93 SLC7A5 (1.00) SLC7A5PTGS1ALPIPKMXIAP
Tyrosine SCHEMBL1581 0.93 SLC7A5 (1.00) SLC7A5PTGS1ALPIPKMXIAP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10005826-B2 Compounds that bind to the erythropoietin receptor EPODOSE LLC (US) 2018-06-26 US disclosed
US-20170029481-A1 Compounds That Bind to the Erythropoietin Receptor EPODOSE LLC (US) 2017-02-02 US disclosed
US-9422338-B2 Compounds that bind to the erythropoietin receptor EPODOSE LLC (US) 2016-08-23 US disclosed
US-20150038403-A1 Compounds That Bind to the Erythropoietin Receptor EPODOSE LLC 2015-02-05 US disclosed
EP-2709648-A2 COMPOUNDS THAT BIND TO THE ERYTHROPOIETIN RECEPTOR Geysen, Hendrik, Mario (US) 2014-03-26 EP disclosed
US-20130012685-A1 NOVEL PEPTIDES THAT BIND TO THE ERYTHROPOIETIN RECEPTOR AFFYMAX, INC. (US) 2013-01-10 US disclosed
WO-2012158493-A2 COMPOUNDS THAT BIND TO THE ERYTHROPOIETIN RECEPTOR GEYSEN HENDRIK M (US) 2012-11-22 WO disclosed
US-8313936-B2 Nucleic acids and polypeptides involved in the production of cryptophycin REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 2012-11-20 US disclosed
US-20120220008-A1 NUCLEIC ACIDS AND POLYPEPTIDES INVOLVED IN THE PRODUCTION OF CRYPTOPHYCIN REGENTS OF THE UNIVERSITY OF MICHIGAN 2012-08-30 US disclosed
US-20120157660-A1 NOVEL PEPTIDES THAT BIND TO THE ERYTHROPOIETIN RECEPTOR AFFYMAX, INC. (US) 2012-06-21 US disclosed
WO-2001068039-A2 HAIR CARE COMPOSITION CONTAINING A POLYALKYLENEGLYCOL(n)ALKYLAMINE THE PROCTER & GAMBLE COMPANY (US) 2001-09-20 WO disclosed
WO-2001068051-A1 HAIR CARE COMPOSITION CONTAINING POLYALKYLENEGLYCOL(n)ALKYLAMINE AND ORGANIC ACID THE PROCTER & GAMBLE COMPANY (US) 2001-09-20 WO disclosed
EP-1133522-A1 ANTAGONISTIC ANALOGS OF GH-RH INHIBITING IGF-I AND -II The Administrators of The Tulane Educational Fund (US) 2001-09-19 EP disclosed
WO-2001058930-A1 PAR4 PEPTIDES AND POLYPEPTIDES ZYMOGENETICS, INC. (US) 2001-08-16 WO disclosed
WO-2000031136-A9 ANTAGONISTIC ANALOGS OF GH-RH INHIBITING IGF-I AND -II UNIV TULANE (US) 2001-07-19 WO disclosed
WO-2000031136-A1 ANTAGONISTIC ANALOGS OF GH-RH INHIBITING IGF-I AND -II ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND (US) 2000-06-02 WO disclosed
US-6057422-A AMINO ACID SEQUENCE OF SYNTHETIC POLYPEPTIDE OF HUMAN GROWTH HORMONE-RELEASING HORMONE WHICH SUPPRESSES RELEASE OF INSULIN-LIKE GROWTH FACTORS; FOR ANTICARCINOGENIC AGENTS THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND (US) 2000-05-02 US disclosed
US-5962407-A CYCLIC DECAPEPTIDES ARE ACTIVE AGAINST BOTH GRAM POSITIVE AND GRAM NEGATIVE BACTERIA. SEATEK MARINE BIOTECHNOLOGY, INC. 1999-10-05 US disclosed
WO-1998004584-A1 CYCLIC DECAPEPTIDE ANTIBIOTICS SEATEK MARINE BIOTECHNOLOGY, INC. (CA) 1998-02-05 WO disclosed
US-4695588-A DECARBOXYLASE INHIBITORS MERCK & CO., INC. (US) 1987-09-22 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130012685-A1 NOVEL PEPTIDES THAT BIND TO THE ERYTHROPOIETIN RECEPTOR EPOR, PROKR1, EDNRB SLC7A5 2604/4885PTGS1 3169/4885ALPI 4211/4885
US-10005826-B2 Compounds that bind to the erythropoietin receptor EPOR, EDNRB, EDNRA SLC7A5 3242/4885PTGS1 2502/4885ALPI 3256/4885
US-20150038403-A1 Compounds That Bind to the Erythropoietin Receptor EPOR, EDNRB, EDNRA SLC7A5 3242/4885PTGS1 2502/4885ALPI 3256/4885
US-20120157660-A1 NOVEL PEPTIDES THAT BIND TO THE ERYTHROPOIETIN RECEPTOR EPOR, PROKR1, EDNRB SLC7A5 2604/4885PTGS1 3169/4885ALPI 4211/4885
US-20170029481-A1 Compounds That Bind to the Erythropoietin Receptor EPOR, EDNRB, EDNRA SLC7A5 3242/4885PTGS1 2502/4885ALPI 3256/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.