Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.66 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.49 |
| ▸ | CRHBP | P24387 | 1/20 | 0.48 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL527567 | 0.82 | HTT (0.72) | HTTTDP1PKMPTGS2LMNA | |
| SCHEMBL29441283 | 0.82 | HTT (0.72) | HTTTDP1PKMPTGS2LMNA | |
| Methyl Alcohol SCHEMBL27770206 | 0.79 | HTT (0.68) | HTTTDP1PKMPTGS2LMNA | |
| SCHEMBL265440 | 0.79 | HTT (0.68) | HTTTDP1PKMPTGS2LMNA | |
| SCHEMBL57125 | 0.79 | HTT (0.68) | HTTTDP1PKMPTGS2LMNA | |
| SCHEMBL222283 | 0.79 | HTT (1.00) | HTTTDP1PKMPTGS2LMNA | |
| SCHEMBL8977874 | 0.79 | HTT (0.68) | HTTTDP1PKMPTGS2LMNA | |
| SCHEMBL9738111 | 0.79 | HTT (0.68) | HTTTDP1PKMPTGS2LMNA | |
| SCHEMBL282839 | 0.78 | HTT (0.66) | HTTTDP1PKMPTGS2LMNA | |
| SCHEMBL446056 | 0.78 | HTT (0.66) | HTTTDP1PKMPTGS2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1995242-B1 | NOVEL 1,2,3,4-TETRAHYDROQUINOXALINE DERIVATIVE HAVING GLUCOCORTICOID RECEPTOR BINDING ACTIVITY | SANTEN PHARMACEUTICAL CO LTD (JP) | 2012-11-07 | — | — | EP | disclosed |