Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 17/20 | 0.72 |
| ▸ | PLK3 | Q9H4B4 | 15/20 | 0.72 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.69 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.69 |
| ▸ | PIM1 | P11309 | 2/20 | 0.69 |
| ▸ | NEK2 | P51955 | 2/20 | 0.69 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.69 |
| ▸ | KDR | P35968 | 1/20 | 0.69 |
| ▸ | CDK2 | P24941 | 1/20 | 0.62 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.62 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.60 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.60 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.60 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.60 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.60 |
| ▸ | STK10 | O94804 | 1/20 | 0.60 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.60 |
| ▸ | KIT | P10721 | 1/20 | 0.60 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.60 |
| ▸ | GRK4 | P32298 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4405034 | 1.00 | PLK1 (0.72) | PLK1PLK3PIK3CDPDGFRBPIM1 | |
| SCHEMBL4397877 | 0.93 | PLK1 (0.65) | PLK1PLK3PIK3CDPDGFRBPIM1 | |
| SCHEMBL5002953 | 0.92 | PLK1 (0.81) | PLK1PLK3PIK3CDPDGFRBPIM1 | |
| SCHEMBL13573245 | 0.92 | PLK1 (0.81) | PLK1PLK3PIK3CDPDGFRBPIM1 | |
| SCHEMBL14029724 | 0.90 | PLK1 (0.62) | PLK1PLK3PIK3CDPDGFRBPIM1 | |
| SCHEMBL4405198 | 0.88 | PLK1 (0.65) | PLK1PLK3PIK3CDPDGFRBPIM1 | |
| SCHEMBL4406302 | 0.88 | PLK1 (0.68) | PLK1PLK3PIK3CDPDGFRBPIM1 | |
| SCHEMBL13573213 | 0.88 | PLK1 (0.68) | PLK1PLK3PIK3CDPDGFRBPIM1 | |
| SCHEMBL14568758 | 0.86 | PLK1 (0.54) | PLK1PLK3PIK3CDPDGFRBPIM1 | |
| SCHEMBL4409927 | 0.85 | PLK1 (0.77) | PLK1PLK3PIK3CDPDGFRBPIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009151914-A1 | METHODS FOR TREATING NEOPLASMS WITH A COMBINATION OF A PLK INHIBITOR AND RETINOID | SMITHKLINE BEECHAM CORPORATION (US) | 2009-12-17 | — | — | WO | disclosed |