SCHEMBL13574255

SCHEMBL13574255

CC(O)C#Cc1ccn2c(-c3cccc(NC(=O)NCC(F)(F)F)c3)cnc2c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
FGFR3 P22607 20/20 1.00
KDR P35968 19/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Formic Acid SCHEMBL11908780 0.98 FGFR3 (0.95) FGFR3KDR
SCHEMBL3323299 0.90 FGFR3 (1.00) FGFR3KDR
SCHEMBL11908781 0.89 FGFR3 (0.80) FGFR3KDR
SCHEMBL3318312 0.88 FGFR3 (0.84) FGFR3KDR
SCHEMBL11909115 0.88 FGFR3 (1.00) FGFR3KDR
SCHEMBL11909162 0.87 FGFR3 (1.00) FGFR3KDR
SCHEMBL3322646 0.87 FGFR3 (0.82) FGFR3KDR
SCHEMBL3321669 0.86 FGFR3 (0.82) FGFR3KDR
SCHEMBL11929124 0.86 FGFR3 (1.00) FGFR3KDR
SCHEMBL11925857 0.86 FGFR3 (1.00) FGFR3KDR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2300465-B1 IMIDAZOPYRIDINE DERIVATIVES AS INHIBITORS OF RECEPTOR TYROSINE KINASES ASTEX THERAPEUTICS LTD (GB) 2019-04-17 EP disclosed
US-8796244-B2 Imidazopyridine derivatives as inhibitors of receptor tyrosine kinases ASTEX THERAPEUTICS LTD (GB) 2014-08-05 US disclosed
WO-2009150240-A1 IMIDAZOPYRIDINE DERIVATIVES AS INHIBITORS OF RECEPTOR TYROSINE KINASES ASTEX THERAPEUTICS LIMITED (GB) 2009-12-17 WO disclosed