Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 15/20 | 0.47 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.31 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.31 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.31 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.31 |
| ▸ | USP9X | Q93008 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL847936 | 0.86 | HRH4 (0.42) | HRH4CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL847746 | 0.79 | HRH4 (0.37) | HRH4CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL846788 | 0.78 | HRH4 (0.56) | HRH4 | |
| SCHEMBL846801 | 0.76 | HRH4 (0.39) | HRH4CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL1588121 | 0.75 | HRH4 (0.45) | HRH4 | |
| SCHEMBL19519110 | 0.74 | HRH4 (0.42) | HRH4CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL846956 | 0.74 | HRH4 (0.64) | HRH4 | |
| SCHEMBL1588623 | 0.74 | HRH4 (0.64) | HRH4 | |
| SCHEMBL1588097 | 0.71 | HRH4 (0.61) | HRH4 | |
| SCHEMBL860792 | 0.71 | HRH4 (0.44) | HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009152325-A1 | DIAMINO-PYRIDINE, PYRIMIDINE, AND PYRIDAZINE MODULATORS OF THE HISTAMINE H4 RECEPTOR | JANSSEN PHARMACEUTICA NV (BE) | 2009-12-17 | — | — | WO | disclosed |