Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.38 |
| ▸ | PAK4 | O96013 | 3/20 | 0.38 |
| ▸ | MAP3K14 | Q99558 | 3/20 | 0.36 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.36 |
| ▸ | PAK2 | Q13177 | 1/20 | 0.36 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.36 |
| ▸ | PAK6 | Q9NQU5 | 1/20 | 0.36 |
| ▸ | PAK5 | Q9P286 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | IL1B | P01584 | 2/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.35 |
| ▸ | CDK7 | P50613 | 1/20 | 0.35 |
| ▸ | CDK9 | P50750 | 1/20 | 0.35 |
| ▸ | CCNH | P51946 | 1/20 | 0.35 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1614081 | 0.87 | PAK4 (0.45) | NPC1RAB9APOLBNR2F2PAK4 | |
| SCHEMBL1614565 | 0.85 | MAP3K14 (0.36) | NPC1RAB9APAK4MAP3K14PAK1 | |
| SCHEMBL1613132 | 0.85 | MAP3K14 (0.38) | NPC1RAB9APOLBNR2F2PAK4 | |
| SCHEMBL1614564 | 0.85 | MAP3K14 (0.36) | NPC1RAB9APAK4MAP3K14PAK1 | |
| SCHEMBL1612516 | 0.84 | CHUK (0.37) | NPC1RAB9APOLBNR2F2PAK4 | |
| SCHEMBL1614094 | 0.84 | PAK4 (0.43) | NPC1RAB9APOLBNR2F2PAK4 | |
| SCHEMBL1614097 | 0.83 | PAK4 (0.44) | NPC1RAB9APOLBNR2F2PAK4 | |
| SCHEMBL1614343 | 0.83 | NPC1 (0.39) | NPC1RAB9APOLBNR2F2PAK4 | |
| SCHEMBL1613465 | 0.83 | MAP3K14 (0.37) | NPC1RAB9APOLBNR2F2PAK4 | |
| SCHEMBL1613513 | 0.82 | PAK4 (0.38) | NPC1RAB9APOLBNR2F2PAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009158011-A1 | ALKYNYL ALCOHOLS AS KINASE INHIBITORS | AMGEN INC. (US) | 2009-12-30 | — | — | WO | disclosed |