Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K14 | Q99558 | 10/20 | 0.39 |
| ▸ | EGFR | P00533 | 4/20 | 0.38 |
| ▸ | AXL | P30530 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.36 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | INSR | P06213 | 1/20 | 0.35 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.35 |
| ▸ | CDK4 | P11802 | 1/20 | 0.35 |
| ▸ | CCND1 | P24385 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.35 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.35 |
| ▸ | MOK | Q9UQ07 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12743915 | 0.88 | MAP3K14 (0.40) | MAP3K14EGFRAXLMAP4K4LRRK2 | |
| SCHEMBL12743933 | 0.88 | MAP3K14 (0.40) | MAP3K14EGFRAXLMAP4K4LRRK2 | |
| SCHEMBL1613384 | 0.84 | MAP3K14 (0.58) | MAP3K14MAP4K4LRRK2AURKBJAK1 | |
| SCHEMBL1612870 | 0.84 | MAP3K14 (0.58) | MAP3K14MAP4K4LRRK2AURKBJAK1 | |
| SCHEMBL1612748 | 0.84 | MAP3K14 (0.58) | MAP3K14MAP4K4LRRK2AURKBJAK1 | |
| SCHEMBL1613343 | 0.76 | CYP2A13 (0.42) | EGFRAXLLRRK2AURKBAURKA | |
| SCHEMBL13575138 | 0.75 | MAP3K14 (0.51) | MAP3K14MAP4K4LRRK2AURKBJAK1 | |
| SCHEMBL12743242 | 0.74 | ALOX5AP (0.36) | MAP3K14EGFRAXLLRRK2AURKB | |
| SCHEMBL1613804 | 0.71 | MAP3K14 (0.50) | MAP3K14 | |
| SCHEMBL12743908 | 0.68 | MAP3K14 (0.50) | MAP3K14MAP4K4LRRK2INSRALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009158011-A1 | ALKYNYL ALCOHOLS AS KINASE INHIBITORS | AMGEN INC. (US) | 2009-12-30 | — | — | WO | disclosed |