Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 3/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 6/20 | 0.37 |
| ▸ | GABRB2 | P47870 | 6/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.37 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 2/20 | 0.36 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.36 |
| ▸ | CETP | P11597 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13578418 | 0.89 | PDE4D (0.41) | HDAC4HDAC2HDAC8PDE4DHTR7 | |
| SCHEMBL13578416 | 0.88 | PDE4B (0.42) | HDAC4HDAC2HDAC8PDE4DHTR7 | |
| SCHEMBL13578467 | 0.88 | PDE4D (0.42) | HDAC4HDAC2HDAC8PDE4DHTR7 | |
| SCHEMBL13578417 | 0.84 | PDE4D (0.44) | PDE4DHTR7 | |
| SCHEMBL13578415 | 0.84 | PDE4D (0.44) | HDAC4HDAC2HDAC8PDE4DHTR7 | |
| SCHEMBL13578466 | 0.83 | PDE4D (0.41) | HDAC4HDAC2HDAC8PDE4DHTR7 | |
| SCHEMBL15906168 | 0.82 | HDAC4 (0.45) | HDAC4HDAC2HDAC8PDE4DHTR7 | |
| SCHEMBL13578408 | 0.82 | PDE4D (0.47) | PDE4DHTR7PDE4B | |
| SCHEMBL13578413 | 0.82 | PDE4D (0.44) | HDAC4HDAC2HDAC8PDE4DHTR7 | |
| SCHEMBL10440089 | 0.81 | PDE4D (0.40) | HDAC4HDAC2HDAC8PDE4DHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090324569-A1 | BIARYL PDE4 INHIBITORS FOR TREATING INFLAMMATORY, CARDIOVASCULAR AND CNS DISORDERS | DECODE GENETICS EHF (IS) | 2009-12-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090324569-A1 | BIARYL PDE4 INHIBITORS FOR TREATING INFLAMMATORY, CARDIOVASCULAR AND CNS DISORDERS | PDE4A, PDE4B, PDE3B | HDAC4 73/4885HDAC2 453/4885HDAC8 913/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.