Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTCH1 | P46531 | 7/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.57 |
| ▸ | HPGD | P15428 | 10/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.57 |
| ▸ | GAA | P10253 | 9/20 | 0.57 |
| ▸ | CASP1 | P29466 | 4/20 | 0.57 |
| ▸ | CASP7 | P55210 | 4/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | GLA | P06280 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | KLK7 | P49862 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15046977 | 0.89 | NOTCH1 (0.57) | NOTCH1KDM4EHPGDALDH1A1GAA | |
| SCHEMBL12137837 | 0.86 | NOTCH1 (0.53) | NOTCH1KDM4EHPGDALDH1A1GAA | |
| SCHEMBL12136009 | 0.86 | KDM4E (0.63) | NOTCH1KDM4EHPGDALDH1A1GAA | |
| SCHEMBL12135705 | 0.84 | KDM4E (0.61) | NOTCH1KDM4EHPGDALDH1A1GAA | |
| SCHEMBL1356628 | 0.80 | NOTCH1 (0.76) | NOTCH1KDM4EHPGDALDH1A1GAA | |
| SCHEMBL1357783 | 0.80 | KDM4E (0.66) | NOTCH1KDM4EHPGDALDH1A1GAA | |
| SCHEMBL3329623 | 0.80 | KDM4E (0.68) | NOTCH1KDM4EHPGDALDH1A1GAA | |
| SCHEMBL1356573 | 0.80 | KDM4E (0.60) | NOTCH1KDM4EHPGDALDH1A1GAA | |
| SCHEMBL12135791 | 0.79 | KDM4E (0.73) | NOTCH1KDM4EHPGDALDH1A1GAA | |
| SCHEMBL12135877 | 0.75 | KDM4E (0.73) | NOTCH1KDM4EHPGDALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9233926-B2 | Compounds for stem cell differentiation | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2016-01-12 | — | — | US | disclosed |
| US-9233926-B2 | Compounds for stem cell differentiation | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2016-01-12 | — | — | US | disclosed |
| US-20130157947-A1 | COMPOUNDS FOR STEM CELL DIFFERENTIATION | Sanford Burnham Prebys Medical Discovery Institute | 2013-06-20 | — | — | US | disclosed |
| US-20130157947-A1 | COMPOUNDS FOR STEM CELL DIFFERENTIATION | Sanford Burnham Prebys Medical Discovery Institute | 2013-06-20 | — | — | US | disclosed |
| WO-2012158568-A1 | COMPOUNDS FOR STEM CELL DIFFERENTIATION | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2012-11-22 | — | — | WO | disclosed |
| WO-2012158568-A1 | COMPOUNDS FOR STEM CELL DIFFERENTIATION | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2012-11-22 | — | — | WO | disclosed |
| US-20110281356-A1 | COMPOUNDS FOR STEM CELL DIFFERENTIATION | HUMAN BIOMOLECULAR RESEARCH INSTITUTE (US) | 2011-11-17 | — | — | US | disclosed |
| US-20110281356-A1 | COMPOUNDS FOR STEM CELL DIFFERENTIATION | HUMAN BIOMOLECULAR RESEARCH INSTITUTE (US) | 2011-11-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130157947-A1 | COMPOUNDS FOR STEM CELL DIFFERENTIATION | MCL1, NES, RUNX1 | NOTCH1 96/4885KDM4E 1601/4885HPGD 3066/4885 |
| US-20110281356-A1 | COMPOUNDS FOR STEM CELL DIFFERENTIATION | MCL1, NES, RUNX1 | NOTCH1 87/4885KDM4E 1648/4885HPGD 2917/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.