Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT3 | P40763 | 1/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 10/20 | 0.47 |
| ▸ | HSP90AB1 | P08238 | 10/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.41 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13509820 | 0.89 | STAT3 (0.59) | STAT3HSP90AA1HSP90AB1PARP14MCL1 | |
| SCHEMBL13509898 | 0.81 | STAT3 (0.55) | STAT3HSP90AA1HSP90AB1MCL1 | |
| SCHEMBL13509814 | 0.79 | STAT3 (0.66) | STAT3HSP90AA1HSP90AB1 | |
| SCHEMBL13509900 | 0.79 | STAT3 (0.53) | STAT3HSP90AA1HSP90AB1PARP14MCL1 | |
| SCHEMBL13509819 | 0.76 | STAT3 (0.61) | STAT3HSP90AA1HSP90AB1PARP14 | |
| SCHEMBL13509822 | 0.74 | STAT3 (0.59) | STAT3HSP90AA1HSP90AB1PARP14 | |
| SCHEMBL13509816 | 0.74 | STAT3 (0.65) | STAT3HSP90AA1HSP90AB1PARP14 | |
| SCHEMBL13509803 | 0.73 | STAT3 (0.67) | STAT3HSP90AA1HSP90AB1MCL1 | |
| SCHEMBL11640095 | 0.73 | EP300 (0.59) | ALDH1A1HPGDPARP14 | |
| SCHEMBL13509902 | 0.73 | STAT3 (0.58) | STAT3HSP90AA1HSP90AB1MCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009149192-A1 | STAT3 INHIBITORS | BAYLOR COLLEGE OF MEDICINE (US) | 2009-12-10 | — | — | WO | disclosed |