Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 15/20 | 0.37 |
| ▸ | JAK2 | O60674 | 12/20 | 0.37 |
| ▸ | JAK1 | P23458 | 14/20 | 0.34 |
| ▸ | HPGDS | O60760 | 1/20 | 0.32 |
| ▸ | TYK2 | P29597 | 3/20 | 0.32 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13580621 | 1.00 | JAK3 (0.37) | JAK3JAK2JAK1HPGDSTYK2 | |
| SCHEMBL13580620 | 1.00 | JAK3 (0.37) | JAK3JAK2JAK1HPGDSTYK2 | |
| SCHEMBL4348877 | 0.86 | JAK2 (0.49) | JAK3JAK2JAK1TYK2 | |
| SCHEMBL4354754 | 0.86 | JAK2 (0.49) | JAK3JAK2JAK1TYK2 | |
| SCHEMBL4346555 | 0.86 | JAK2 (0.49) | JAK3JAK2JAK1TYK2 | |
| SCHEMBL4348867 | 0.86 | JAK2 (0.49) | JAK3JAK2JAK1TYK2 | |
| SCHEMBL1536833 | 0.79 | JAK3 (0.42) | JAK3JAK2JAK1TYK2 | |
| SCHEMBL4355902 | 0.79 | JAK3 (0.42) | JAK3JAK2JAK1TYK2 | |
| SCHEMBL13579873 | 0.79 | JAK3 (0.42) | JAK3JAK2JAK1TYK2 | |
| SCHEMBL13580572 | 0.78 | RET (0.40) | JAK3JAK2JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009152133-A1 | NOVEL TRICYCLIC COMPOUNDS | ABBOTT LABORATORIES (US) | 2009-12-17 | — | — | WO | disclosed |