Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 18/20 | 0.72 |
| ▸ | PDGFRA | P16234 | 6/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.56 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.55 |
| ▸ | AURKA | O14965 | 1/20 | 0.55 |
| ▸ | LCK | P06239 | 1/20 | 0.55 |
| ▸ | CSF1R | P07333 | 1/20 | 0.55 |
| ▸ | MET | P08581 | 1/20 | 0.55 |
| ▸ | BRAF | P15056 | 1/20 | 0.55 |
| ▸ | FLT1 | P17948 | 1/20 | 0.55 |
| ▸ | FLT4 | P35916 | 1/20 | 0.55 |
| ▸ | TEK | Q02763 | 1/20 | 0.55 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.55 |
| ▸ | KIT | P10721 | 1/20 | 0.54 |
| ▸ | AXL | P30530 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13587177 | 0.92 | PDGFRA (0.66) | KDRPDGFRACYP3A4CYP2D6FGFR2 | |
| SCHEMBL13587178 | 0.91 | KDR (0.69) | KDRPDGFRACYP3A4CYP2D6FGFR2 | |
| SCHEMBL13587182 | 0.88 | KDR (0.66) | KDRPDGFRACYP3A4CYP2D6FGFR2 | |
| SCHEMBL13587181 | 0.85 | KDR (0.69) | KDRPDGFRAFGFR2AURKALCK | |
| SCHEMBL13587179 | 0.84 | KDR (0.62) | KDRPDGFRACYP3A4CYP2D6FGFR2 | |
| SCHEMBL13587188 | 0.84 | KDR (0.55) | KDRPDGFRACYP3A4CYP2D6FGFR2 | |
| SCHEMBL13587184 | 0.84 | KDR (0.70) | KDRPDGFRACYP3A4CYP2D6FGFR2 | |
| SCHEMBL4548844 | 0.84 | KDR (1.00) | KDRCYP3A4CYP2D6FGFR2AURKA | |
| SCHEMBL2747734 | 0.84 | KDR (0.75) | KDRPDGFRACYP3A4CYP2D6FGFR2 | |
| SCHEMBL13587189 | 0.83 | KDR (0.54) | KDRPDGFRACYP3A4CYP2D6FGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7626030-B2 | Compounds and methods of use | AMGEN INC. (US) | 2009-12-01 | — | — | US | disclosed |
| US-7626030-B2 | Compounds and methods of use | AMGEN INC. (US) | 2009-12-01 | — | — | US | disclosed |