Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RYR2 | Q92736 | 20/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6866692 | 0.85 | RYR2 (1.00) | RYR2 | |
| SCHEMBL13632613 | 0.85 | RYR2 (0.80) | RYR2 | |
| SCHEMBL12265394 | 0.84 | RYR2 (0.77) | RYR2 | |
| SCHEMBL6867956 | 0.84 | RYR2 (0.78) | RYR2 | |
| SCHEMBL12265368 | 0.83 | RYR2 (0.81) | RYR2 | |
| SCHEMBL6867436 | 0.81 | RYR2 (0.73) | RYR2 | |
| SCHEMBL8244596 | 0.81 | RYR2 (0.73) | RYR2 | |
| SCHEMBL12265304 | 0.80 | RYR2 (0.77) | RYR2 | |
| SCHEMBL6867272 | 0.79 | RYR2 (1.00) | RYR2 | |
| SCHEMBL6866695 | 0.79 | RYR2 (1.00) | RYR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2127654-A1 | Benzothiazepine derivatives as ryanodine receptor (RYR2) inhibitors and their use in the treatment of cardiac diseases | The Trustees of Columbia University in the City of New York (US) | 2009-12-02 | — | — | EP | disclosed |