Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNN4 | O15554 | 12/20 | 0.36 |
| ▸ | EP300 | Q09472 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | ESR1 | P03372 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | NAMPT | P43490 | 1/20 | 0.31 |
| ▸ | FABP7 | O15540 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13593400 | 0.92 | KCNN4 (0.34) | KCNN4EP300PIK3CAMAPK1HDAC1 | |
| SCHEMBL984712 | 0.89 | PIK3CA (0.36) | KCNN4PIK3CAMAPK1HDAC1HDAC6 | |
| SCHEMBL987742 | 0.86 | KCNN4 (0.37) | KCNN4EP300MAPK1HDAC6NAMPT | |
| SCHEMBL986709 | 0.83 | PIK3CA (0.40) | PIK3CA | |
| SCHEMBL986957 | 0.83 | KCNN4 (0.37) | KCNN4MAPK1 | |
| SCHEMBL985226 | 0.82 | KCNN4 (0.36) | KCNN4MAPK1 | |
| SCHEMBL986318 | 0.81 | KCNN4 (0.37) | KCNN4MAPK1 | |
| SCHEMBL984501 | 0.81 | KCNN4 (0.38) | KCNN4MAPK1 | |
| SCHEMBL985298 | 0.81 | PIK3CA (0.38) | KCNN4PIK3CA | |
| SCHEMBL985410 | 0.80 | PIK3CA (0.39) | KCNN4PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2004625-B1 | C-MET PROTEIN KINASE INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | VERTEX PHARMA (US) | 2009-12-30 | — | — | EP | disclosed |