Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 4/20 | 0.63 |
| ▸ | ACHE | P22303 | 4/20 | 0.63 |
| ▸ | FAAH | O00519 | 1/20 | 0.63 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.63 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.63 |
| ▸ | PDE5A | O76074 | 1/20 | 0.63 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.63 |
| ▸ | APP | P05067 | 1/20 | 0.63 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.63 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.63 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.63 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.63 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.63 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.63 |
| ▸ | DRD4 | P21917 | 1/20 | 0.63 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.63 |
| ▸ | MAOB | P27338 | 1/20 | 0.63 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.63 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL678139 | 0.88 | BCHE (0.69) | BCHEACHEFAAHABCC4CACNA1F | |
| SCHEMBL676837 | 0.88 | BCHE (0.69) | BCHEACHEFAAHABCC4CACNA1F | |
| SCHEMBL676836 | 0.88 | BCHE (0.69) | BCHEACHEFAAHABCC4CACNA1F | |
| SCHEMBL6867659 | 0.88 | BCHE (0.69) | BCHEACHEFAAHABCC4CACNA1F | |
| SCHEMBL13144547 | 0.84 | BCHE (0.82) | BCHEACHEFAAHABCC4CACNA1F | |
| SCHEMBL8281051 | 0.84 | BCHE (0.66) | BCHEACHEFAAHABCC4CACNA1F | |
| SCHEMBL24390900 | 0.83 | BCHE (0.74) | BCHEACHEFAAHABCC4CACNA1F | |
| SCHEMBL14539983 | 0.83 | BCHE (0.70) | BCHEACHEFAAHABCC4CACNA1F | |
| Donepezil SCHEMBL14485424 | 0.81 | BCHE (0.90) | BCHEACHEFAAHABCC4CACNA1F | |
| Donepezil SCHEMBL6276198 | 0.80 | BCHE (0.86) | BCHEACHEFAAHABCC4CACNA1F |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2130538-A1 | Use of a cholinesterase inhibitor for the delaying the onset of Alzheimer's disease | Eisai R&D Management Co., Ltd. (JP) | 2009-12-09 | — | — | EP | disclosed |