Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 2/20 | 0.39 |
| ▸ | AKT2 | P31751 | 2/20 | 0.39 |
| ▸ | AKT3 | Q9Y243 | 2/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.37 |
| ▸ | CIT | O14578 | 1/20 | 0.37 |
| ▸ | PRKCB | P05771 | 1/20 | 0.37 |
| ▸ | PRKCA | P17252 | 1/20 | 0.37 |
| ▸ | PRKACA | P17612 | 1/20 | 0.37 |
| ▸ | PRKACB | P22694 | 1/20 | 0.37 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.37 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.37 |
| ▸ | PIN1 | Q13526 | 4/20 | 0.35 |
| ▸ | CTSV | O60911 | 1/20 | 0.34 |
| ▸ | CTSL | P07711 | 1/20 | 0.34 |
| ▸ | CTSB | P07858 | 1/20 | 0.34 |
| ▸ | CTSS | P25774 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | SCD | O00767 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1571997 | 0.95 | AKT1 (0.41) | AKT1AKT2AKT3ROCK1ROCK2 | |
| SCHEMBL13601556 | 0.87 | AKT1 (0.41) | AKT1AKT2AKT3ROCK1ROCK2 | |
| SCHEMBL1572598 | 0.82 | AKT1 (0.53) | AKT1AKT2AKT3ROCK1ROCK2 | |
| SCHEMBL1572737 | 0.81 | AKT1 (0.43) | AKT1AKT2AKT3ROCK1ROCK2 | |
| SCHEMBL1572750 | 0.80 | AKT1 (0.48) | AKT1AKT2AKT3ROCK1ROCK2 | |
| SCHEMBL12531513 | 0.79 | ROCK1 (0.55) | AKT1AKT2AKT3ROCK1ROCK2 | |
| SCHEMBL1573014 | 0.78 | AKT1 (0.43) | AKT1AKT2AKT3ROCK1ROCK2 | |
| SCHEMBL13601387 | 0.77 | AKT1 (0.46) | AKT1AKT2AKT3ROCK1ROCK2 | |
| SCHEMBL1641424 | 0.74 | AKT1 (0.45) | AKT1AKT2AKT3ROCK1ROCK2 | |
| SCHEMBL678161 | 0.73 | AKT1 (0.42) | AKT1AKT2AKT3ROCK1ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009158371-A1 | INHIBITORS OF AKT ACTIVITY | SMITHKLIKE BEECHAM CORPORATION (US) | 2009-12-30 | — | — | WO | disclosed |