Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 19/20 | 0.56 |
| ▸ | MAP2K2 | P36507 | 3/20 | 0.56 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.56 |
| ▸ | SMC2 | O95347 | 1/20 | 0.56 |
| ▸ | EGFR | P00533 | 1/20 | 0.56 |
| ▸ | SMC1A | Q14683 | 1/20 | 0.56 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.56 |
| ▸ | Q6ZSR9 | Q6ZSR9 | 1/20 | 0.56 |
| ▸ | BMP2K | Q9NSY1 | 1/20 | 0.56 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.47 |
| ▸ | NQO2 | P16083 | 1/20 | 0.47 |
| ▸ | RAF1 | P04049 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.47 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.47 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.47 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.47 |
| ▸ | AURKC | Q9UQB9 | 1/20 | 0.47 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4546079 | 0.93 | MAP2K1 (0.56) | MAP2K1MAP2K2CSNK2A2SMC2EGFR | |
| SCHEMBL4546096 | 0.92 | MAP2K1 (0.56) | MAP2K1MAP2K2CSNK2A2SMC2EGFR | |
| SCHEMBL19140890 | 0.91 | MAP2K1 (0.55) | MAP2K1MAP2K2CSNK2A2SMC2EGFR | |
| SCHEMBL1041673 | 0.91 | MAP2K1 (0.61) | MAP2K1MAP2K2CSNK2A2SMC2EGFR | |
| SCHEMBL4546084 | 0.90 | MAP2K1 (0.54) | MAP2K1MAP2K2CSNK2A2SMC2EGFR | |
| SCHEMBL4545992 | 0.90 | MAP2K1 (0.61) | MAP2K1MAP2K2CSNK2A2SMC2EGFR | |
| SCHEMBL4546087 | 0.90 | MAP2K1 (0.56) | MAP2K1MAP2K2CSNK2A2SMC2EGFR | |
| SCHEMBL4546088 | 0.90 | MAP2K1 (0.56) | MAP2K1MAP2K2CSNK2A2SMC2EGFR | |
| SCHEMBL4546075 | 0.90 | MAP2K1 (0.60) | MAP2K1MAP2K2CSNK2A2SMC2EGFR | |
| SCHEMBL18752739 | 0.90 | MAP2K1 (0.55) | MAP2K1MAP2K2CSNK2A2SMC2EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3000810-B1 | N3 ALKYLATED BENZIMIDAZOLE DERIVATIVE AS MEK INHIBITOR | ARRAY BIOPHARMA INC (US) | 2017-07-19 | — | — | EP | disclosed |
| EP-3000810-A1 | N3 ALKYLATED BENZIMIDAZOLE DERIVATIVE AS MEK INHIBITOR | Array Biopharma, Inc. (US) | 2016-03-30 | — | — | EP | disclosed |
| EP-2130536-A1 | N3 alkylated benzimidazole derivatives as mek inhibitors | Array Biopharma, Inc. (US) | 2009-12-09 | — | — | EP | disclosed |