Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 8/20 | 0.55 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.55 |
| ▸ | RET | P07949 | 3/20 | 0.55 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.55 |
| ▸ | HIPK4 | Q8NE63 | 3/20 | 0.55 |
| ▸ | PLK4 | O00444 | 2/20 | 0.55 |
| ▸ | AURKA | O14965 | 2/20 | 0.55 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.55 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.55 |
| ▸ | ABL1 | P00519 | 2/20 | 0.55 |
| ▸ | LCK | P06239 | 2/20 | 0.55 |
| ▸ | FYN | P06241 | 2/20 | 0.55 |
| ▸ | LYN | P07948 | 2/20 | 0.55 |
| ▸ | SRC | P12931 | 2/20 | 0.55 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.55 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.55 |
| ▸ | AXL | P30530 | 2/20 | 0.55 |
| ▸ | FRK | P42685 | 2/20 | 0.55 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.55 |
| ▸ | BLK | P51451 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13603622 | 0.91 | MAPK14 (0.58) | KDRMAPK14RETAURKBHIPK4 | |
| SCHEMBL13603590 | 0.91 | KDR (0.59) | KDRMAPK14RETAURKBHIPK4 | |
| SCHEMBL15573040 | 0.89 | KDR (0.56) | KDRMAPK14RETAURKBHIPK4 | |
| SCHEMBL13603809 | 0.86 | KDR (0.61) | KDRMAPK14RETAURKBHIPK4 | |
| SCHEMBL171153 | 0.86 | KDR (0.55) | KDRMAPK14RETAURKBHIPK4 | |
| SCHEMBL171273 | 0.85 | KDR (0.61) | KDRMAPK14RETAURKBHIPK4 | |
| SCHEMBL13603520 | 0.84 | BRAF (0.59) | KDRMAPK14RETAURKBHIPK4 | |
| SCHEMBL15574673 | 0.84 | KDR (0.57) | KDRMAPK14RETAURKBHIPK4 | |
| SCHEMBL13603542 | 0.84 | MAPK14 (0.58) | KDRMAPK14RETAURKBHIPK4 | |
| SCHEMBL171257 | 0.83 | RET (0.59) | KDRMAPK14RETAURKBHIPK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130158076-A1 | Methylene Urea Derivatives | MERCK PATENT GMBH (DE) | 2013-06-20 | — | — | US | disclosed |
| US-8410143-B2 | Methylene urea derivatives | MERCK PATENT GMBH (DE) | 2013-04-02 | — | — | US | disclosed |
| US-8410143-B2 | Methylene urea derivatives | MERCK PATENT GMBH (DE) | 2013-04-02 | — | — | US | disclosed |
| US-20090298885-A1 | METHYLENE UREA DERIVATIVES | MERCK PATENT GMBH (DE) | 2009-12-03 | — | — | US | disclosed |
| US-20090298885-A1 | METHYLENE UREA DERIVATIVES | MERCK PATENT GMBH (DE) | 2009-12-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090298885-A1 | METHYLENE UREA DERIVATIVES | BRAF, RAF1, CMPK1 | KDR 1819/4885MAPK14 120/4885RET 85/4885 |
| US-20130158076-A1 | Methylene Urea Derivatives | BRAF, RAF1, CMPK1 | KDR 1819/4885MAPK14 120/4885RET 85/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.