Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 7/20 | 0.44 |
| ▸ | ACACA | Q13085 | 7/20 | 0.44 |
| ▸ | DRD4 | P21917 | 3/20 | 0.42 |
| ▸ | FAAH | O00519 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | GPR183 | P32249 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3098157 | 1.00 | ACACB (0.44) | ACACBACACADRD4FAAHTP53 | |
| SCHEMBL13157695 | 0.86 | ACACB (0.57) | ACACBACACA | |
| SCHEMBL3098588 | 0.83 | MCHR1 (0.55) | DRD4FAAHMCHR1GPR183 | |
| SCHEMBL13157922 | 0.83 | MCHR1 (0.55) | DRD4FAAHMCHR1GPR183 | |
| SCHEMBL13182425 | 0.83 | MCHR1 (0.55) | DRD4FAAHMCHR1GPR183 | |
| SCHEMBL13157902 | 0.82 | GRIN2B (0.57) | TP53 | |
| SCHEMBL3093260 | 0.82 | GRIN2B (0.57) | TP53 | |
| SCHEMBL3109744 | 0.82 | GRIN2B (0.59) | DRD4FAAHTP53SIGMAR1 | |
| SCHEMBL13157898 | 0.82 | GRIN2B (0.59) | DRD4FAAHTP53SIGMAR1 | |
| SCHEMBL3099510 | 0.82 | GPR183 (0.58) | TP53GPR183 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8399455-B2 | Compounds useful as chemokine receptor antagonists | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2013-03-19 | — | — | US | disclosed |
| US-8399455-B2 | Compounds useful as chemokine receptor antagonists | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2013-03-19 | — | — | US | disclosed |
| US-7635698-B2 | Compounds useful as chemokine receptor antagonists | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2009-12-22 | — | — | US | disclosed |
| US-7635698-B2 | Compounds useful as chemokine receptor antagonists | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2009-12-22 | — | — | US | disclosed |