Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 2/20 | 0.44 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.44 |
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.40 |
| ▸ | ACKR3 | P25106 | 9/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.38 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 2/20 | 0.38 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4490858 | 0.87 | SIRT2 (0.48) | USP30SIRT2ACKR3JAK2JAK1 | |
| SCHEMBL13604611 | 0.87 | JAK2 (0.49) | SCN9AUSP30ACKR3JAK2JAK1 | |
| SCHEMBL13604571 | 0.87 | SIRT2 (0.48) | USP30SIRT2ACKR3JAK2JAK1 | |
| SCHEMBL13604610 | 0.87 | JAK2 (0.49) | SCN9AUSP30ACKR3JAK2JAK1 | |
| SCHEMBL13604580 | 0.81 | SIRT2 (0.46) | USP30SIRT2ACKR3PARP1PARP2 | |
| SCHEMBL5927859 | 0.80 | JAK1 (0.42) | USP30JAK2JAK1 | |
| SCHEMBL13604570 | 0.80 | SIRT2 (0.41) | SCN9ASIRT2ACKR3PARP1 | |
| SCHEMBL4484577 | 0.79 | SIRT2 (0.48) | SIRT2 | |
| SCHEMBL5927772 | 0.75 | POLB (0.49) | — | |
| SCHEMBL6632099 | 0.74 | PTPN2 (0.47) | SCN9AUSP30SCN3ASCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7635697-B2 | Farnesyl protein transferase inhibitors and methods for treating proliferative diseases | SCHERING CORPORATION (US) | 2009-12-22 | — | — | US | disclosed |
| US-7635697-B2 | Farnesyl protein transferase inhibitors and methods for treating proliferative diseases | SCHERING CORPORATION (US) | 2009-12-22 | — | — | US | disclosed |