Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 18/20 | 0.56 |
| ▸ | ESR2 | Q92731 | 18/20 | 0.56 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.39 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3922723 | 0.85 | ESR1 (0.63) | ESR1ESR2HSD17B1HSD17B2 | |
| SCHEMBL3928048 | 0.81 | ESR1 (0.65) | ESR1ESR2 | |
| SCHEMBL3925753 | 0.81 | ESR1 (0.67) | ESR1ESR2 | |
| SCHEMBL3921680 | 0.81 | ESR1 (0.65) | ESR1ESR2 | |
| SCHEMBL3926517 | 0.81 | ESR1 (0.50) | ESR1ESR2 | |
| SCHEMBL13607750 | 0.80 | ESR1 (0.49) | ESR1ESR2HSD17B1HSD17B2 | |
| SCHEMBL3936448 | 0.79 | ESR1 (0.50) | ESR1ESR2 | |
| SCHEMBL13607763 | 0.77 | ESR1 (0.71) | ESR1ESR2 | |
| SCHEMBL3922463 | 0.77 | ESR1 (0.63) | ESR1ESR2 | |
| SCHEMBL3925647 | 0.76 | ESR1 (0.45) | ESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632845-B2 | 2-(p-oxyphenyl)-6-oxyquinolines, e.g., 2-(3-Fluoro-4-hydroxyphenyl)-4-phenylquinolin-6-ol; inflammatory bowel disease; Crohn's disease; anticarcinogenic agents; anticholesterol agents; antilipemic agents; cardiovascular diorders; osteoporosis; A lzheimer's disease; fertility; antiarthritic agents | WYETH (US) | 2009-12-15 | — | — | US | disclosed |