Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.46 |
| ▸ | FYN | P06241 | 4/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | PDE5A | O76074 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.40 |
| ▸ | GSK3A | P49840 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.40 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.40 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13608555 | 0.86 | PDGFRB (0.49) | KITPDGFRBPDGFRAFYNPDE5A | |
| SCHEMBL13608564 | 0.84 | AURKA (0.51) | KITFYNAURKACDK1GSK3A | |
| SCHEMBL4053763 | 0.84 | AURKA (0.56) | KITPDGFRBPDGFRAFYNAURKA | |
| SCHEMBL13608578 | 0.82 | KIT (0.48) | KITPDGFRBPDGFRAKMT2AGSK3A | |
| SCHEMBL13608583 | 0.82 | PDGFRB (0.46) | PDGFRBPDGFRAKMT2ACYP1A2CYP3A4 | |
| SCHEMBL13608369 | 0.81 | PDGFRB (0.45) | PDGFRBPDGFRAFYNPDE5AKMT2A | |
| SCHEMBL13608587 | 0.81 | PDGFRB (0.46) | KITPDGFRBPDGFRAAURKAKMT2A | |
| SCHEMBL13608559 | 0.81 | PDGFRB (0.51) | KITPDGFRBPDGFRAPDE5ACCNB2 | |
| SCHEMBL13608537 | 0.79 | PDGFRB (0.53) | KITPDGFRBPDGFRAFYNAURKA | |
| SCHEMBL13608571 | 0.79 | PDGFRB (0.54) | PDGFRBPDGFRAAURKAPDE5ACCNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622479-B2 | Bicyclic derivative, its production and use | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-11-24 | — | — | US | disclosed |
| US-7622479-B2 | Bicyclic derivative, its production and use | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-11-24 | — | — | US | disclosed |