Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | YES1 | P07947 | 6/20 | 1.00 |
| ▸ | PDGFRB | P09619 | 6/20 | 1.00 |
| ▸ | EPHB4 | P54760 | 4/20 | 1.00 |
| ▸ | SRC | P12931 | 19/20 | 0.72 |
| ▸ | ABL1 | P00519 | 3/20 | 0.72 |
| ▸ | LCK | P06239 | 3/20 | 0.72 |
| ▸ | LYN | P07948 | 3/20 | 0.72 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.72 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.72 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.72 |
| ▸ | KDR | P35968 | 2/20 | 0.72 |
| ▸ | EGFR | P00533 | 1/20 | 0.72 |
| ▸ | RAF1 | P04049 | 1/20 | 0.72 |
| ▸ | FYN | P06241 | 1/20 | 0.72 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.72 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.72 |
| ▸ | CSK | P41240 | 1/20 | 0.72 |
| ▸ | BLK | P51451 | 1/20 | 0.72 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.72 |
| ▸ | TEK | Q02763 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13609488 | 0.93 | PDGFRB (0.87) | YES1PDGFRBEPHB4SRCABL1 | |
| SCHEMBL4269573 | 0.84 | SRC (1.00) | YES1PDGFRBEPHB4SRCABL1 | |
| SCHEMBL4264223 | 0.83 | SRC (1.00) | YES1PDGFRBEPHB4SRCABL1 | |
| SCHEMBL4265763 | 0.83 | SRC (1.00) | YES1PDGFRBEPHB4SRCABL1 | |
| SCHEMBL4273044 | 0.81 | SRC (1.00) | YES1PDGFRBEPHB4SRCABL1 | |
| SCHEMBL4265948 | 0.81 | SRC (1.00) | YES1PDGFRBEPHB4SRCABL1 | |
| SCHEMBL4264260 | 0.80 | SRC (1.00) | YES1PDGFRBEPHB4SRCABL1 | |
| SCHEMBL4266662 | 0.80 | SRC (1.00) | YES1PDGFRBEPHB4SRCABL1 | |
| SCHEMBL4272220 | 0.80 | SRC (1.00) | YES1PDGFRBEPHB4SRCABL1 | |
| SCHEMBL15683076 | 0.79 | SRC (0.85) | YES1PDGFRBEPHB4SRCABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8481536-B2 | Benzotriazine inhibitors of kinases | TARGEGEN, INC. (US) | 2013-07-09 | — | — | US | disclosed |
| US-8481536-B2 | Benzotriazine inhibitors of kinases | TARGEGEN, INC. (US) | 2013-07-09 | — | — | US | disclosed |
| US-20110294796-A1 | BENZOTRIAZINE INHIBITORS OF KINASES | TARGEGEN, INC. (US) | 2011-12-01 | — | — | US | disclosed |
| US-20110294796-A1 | BENZOTRIAZINE INHIBITORS OF KINASES | TARGEGEN, INC. (US) | 2011-12-01 | — | — | US | disclosed |
| US-20090275569-A1 | Benzotriazine Inhibitors of Kinases | TARGEGEN, INC. | 2009-11-05 | — | — | US | disclosed |
| US-20090275569-A1 | Benzotriazine Inhibitors of Kinases | TARGEGEN, INC. | 2009-11-05 | — | — | US | disclosed |
| US-7456176-B2 | Benzotriazine inhibitors of kinases | TARGEGEN, INC. (US) | 2008-11-25 | — | — | US | disclosed |
| US-7456176-B2 | Benzotriazine inhibitors of kinases | TARGEGEN, INC. (US) | 2008-11-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110294796-A1 | BENZOTRIAZINE INHIBITORS OF KINASES | SRC, CAMK4, CAMK2G | YES1 237/4885PDGFRB 221/4885EPHB4 2376/4885 |
| US-20090275569-A1 | Benzotriazine Inhibitors of Kinases | SRC, CAMK4, CAMK2G | YES1 237/4885PDGFRB 221/4885EPHB4 2376/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.