Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | MET | P08581 | 3/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | BRAF | P15056 | 6/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4458348 | 0.86 | AURKA (0.54) | AURKAKCNH2SCN5ASCN9AALDH1A1 | |
| SCHEMBL13603043 | 0.85 | FGFR2 (0.42) | AURKAKDRBRAFMAOAMAOB | |
| SCHEMBL12652265 | 0.84 | LYN (0.43) | ALDH1A1BRAF | |
| SCHEMBL13610570 | 0.80 | BRAF (0.46) | PDGFRAKDRBRAF | |
| SCHEMBL13603061 | 0.78 | BRAF (0.44) | PDGFRAKDRBRAF | |
| SCHEMBL13603256 | 0.78 | PSMB8 (0.43) | BRAF | |
| SCHEMBL1796270 | 0.76 | AURKA (0.40) | AURKAALDH1A1BRAFMAOBMAPT | |
| SCHEMBL12615637 | 0.76 | AURKA (0.38) | AURKAKDRBRAF | |
| SCHEMBL3631219 | 0.75 | PDE3B (0.40) | AURKAKDR | |
| SCHEMBL13603221 | 0.74 | BRAF (0.60) | BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7625922-B2 | Imidazo[4,5-b]pyridin-2-one and oxazolo[4,5-b]pyridin-2-one compounds and analogs thereof as therapeutic compounds | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2009-12-01 | — | — | US | disclosed |