Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 19/20 | 0.51 |
| ▸ | MAP2K2 | P36507 | 3/20 | 0.51 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.51 |
| ▸ | EIF2AK1 | Q9BQI3 | 1/20 | 0.51 |
| ▸ | SMC2 | O95347 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.46 |
| ▸ | SMC1A | Q14683 | 1/20 | 0.46 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.46 |
| ▸ | Q6ZSR9 | Q6ZSR9 | 1/20 | 0.46 |
| ▸ | BMP2K | Q9NSY1 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL392604 | 0.91 | MAP2K1 (0.56) | MAP2K1MAP2K2MAP2K5EIF2AK1SMC2 | |
| SCHEMBL391286 | 0.89 | MAP2K1 (0.59) | MAP2K1MAP2K2MAP2K5EIF2AK1SMC2 | |
| SCHEMBL14067801 | 0.89 | MAP2K1 (0.48) | MAP2K1MAP2K2MAP2K5EIF2AK1SMC2 | |
| SCHEMBL392252 | 0.88 | MAP2K1 (0.63) | MAP2K1MAP2K2MAP2K5EIF2AK1KCNH2 | |
| SCHEMBL388837 | 0.81 | MAP2K1 (0.69) | MAP2K1MAP2K2MAP2K5EIF2AK1KCNH2 | |
| SCHEMBL393671 | 0.79 | MAP2K1 (0.65) | MAP2K1MAP2K2MAP2K5EIF2AK1SMC2 | |
| SCHEMBL13070149 | 0.79 | MAP2K1 (0.59) | MAP2K1MAP2K2MAP2K5EIF2AK1KCNH2 | |
| SCHEMBL393023 | 0.79 | MAP2K1 (0.76) | MAP2K1MAP2K2MAP2K5EIF2AK1KCNH2 | |
| SCHEMBL15296648 | 0.78 | HPGD (0.52) | MAP2K1 | |
| SCHEMBL23187890 | 0.78 | MAP2K1 (0.68) | MAP2K1MAP2K2MAP2K5EIF2AK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1967516-B1 | 4-(phenylamino)-6-oxo-1,6-dihydropyridazine-3-carboxamide derivatives as MEK inhibitors for the treatment of hyperproliferative diseases | ARRAY BIOPHARMA INC (US) | 2009-11-04 | — | — | EP | disclosed |