Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 18/20 | 0.48 |
| ▸ | MAP2K2 | P36507 | 5/20 | 0.48 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.48 |
| ▸ | EIF2AK1 | Q9BQI3 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | RAF1 | P04049 | 1/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.33 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.33 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.33 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.33 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.33 |
| ▸ | AURKC | Q9UQB9 | 1/20 | 0.33 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL393665 | 0.83 | MAP2K1 (0.60) | MAP2K1MAP2K2MAP2K5EIF2AK1LMNA | |
| SCHEMBL392221 | 0.77 | MAP2K1 (0.79) | MAP2K1MAP2K2MAP2K5EIF2AK1CSNK2A2 | |
| SCHEMBL391638 | 0.76 | MAP2K1 (0.61) | MAP2K1MAP2K2MAP2K5EIF2AK1RAF1 | |
| SCHEMBL391639 | 0.76 | MAP2K1 (0.61) | MAP2K1MAP2K2MAP2K5EIF2AK1RAF1 | |
| SCHEMBL3809583 | 0.76 | MAP2K1 (0.45) | MAP2K1MAP2K2MAP2K5EIF2AK1LMNA | |
| SCHEMBL390239 | 0.73 | MAP2K1 (0.68) | MAP2K1MAP2K2MAP2K5EIF2AK1 | |
| SCHEMBL1776186 | 0.72 | MAP2K1 (0.71) | MAP2K1MAP2K2MAP2K5EIF2AK1 | |
| SCHEMBL392291 | 0.71 | MAP2K1 (0.77) | MAP2K1MAP2K2MAP2K5EIF2AK1 | |
| SCHEMBL486804 | 0.70 | MAP2K1 (0.69) | MAP2K1MAP2K2MAP2K5EIF2AK1IDO1 | |
| SCHEMBL13063573 | 0.70 | MAP2K1 (0.55) | MAP2K1MAP2K2MAP2K5EIF2AK1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1967516-B1 | 4-(phenylamino)-6-oxo-1,6-dihydropyridazine-3-carboxamide derivatives as MEK inhibitors for the treatment of hyperproliferative diseases | ARRAY BIOPHARMA INC (US) | 2009-11-04 | — | — | EP | disclosed |