Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 16/20 | 0.41 |
| ▸ | MAP2K2 | P36507 | 5/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
| ▸ | RAF1 | P04049 | 1/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.35 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.35 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.35 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.35 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.35 |
| ▸ | AURKC | Q9UQB9 | 1/20 | 0.35 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12021813 | 0.88 | MAP2K1 (0.43) | MAP2K1MAP2K2CSNK2A2 | |
| SCHEMBL388862 | 0.87 | MAP2K1 (0.52) | MAP2K1MAP2K2 | |
| SCHEMBL388771 | 0.85 | MAP2K1 (0.49) | MAP2K1MAP2K2CSNK2A2 | |
| SCHEMBL391769 | 0.82 | KCNH2 (0.45) | MAP2K1MAP2K2RAF1PDGFRBCSNK2A2 | |
| SCHEMBL391768 | 0.82 | KCNH2 (0.45) | MAP2K1MAP2K2RAF1PDGFRBCSNK2A2 | |
| SCHEMBL392151 | 0.79 | MAP2K1 (0.50) | MAP2K1MAP2K2 | |
| SCHEMBL392921 | 0.76 | MAP2K1 (0.58) | MAP2K1MAP2K2 | |
| SCHEMBL391635 | 0.76 | MAP2K1 (0.53) | MAP2K1MAP2K2 | |
| SCHEMBL1516515 | 0.75 | MAP2K1 (0.53) | MAP2K1MAP2K2 | |
| SCHEMBL391524 | 0.75 | MAP2K1 (0.52) | MAP2K1MAP2K2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1967516-B1 | 4-(phenylamino)-6-oxo-1,6-dihydropyridazine-3-carboxamide derivatives as MEK inhibitors for the treatment of hyperproliferative diseases | ARRAY BIOPHARMA INC (US) | 2009-11-04 | — | — | EP | disclosed |
| EP-1967516-A1 | 4-(phenylamino)-6-oxo-1,6-dihydropyridazine-3-carboxamide derivatives as MEK inhibitors for the treatment of hyperproliferative diseases | Array Biopharma, Inc. (US) | 2008-09-10 | — | — | EP | disclosed |