Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA2 | P42262 | 18/20 | 0.69 |
| ▸ | GRIA4 | P48058 | 18/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8289639 | 0.91 | GRIA2 (0.68) | GRIA2GRIA4ALDH1A1 | |
| SCHEMBL8288504 | 0.91 | GRIA2 (0.68) | GRIA2GRIA4 | |
| SCHEMBL8288494 | 0.91 | GRIA4 (0.66) | GRIA2GRIA4 | |
| SCHEMBL8288409 | 0.91 | GRIA2 (0.55) | GRIA2GRIA4ALDH1A1SMN1; SMN2POLB | |
| SCHEMBL8289582 | 0.90 | GRIA2 (0.57) | GRIA2GRIA4 | |
| SCHEMBL8289634 | 0.90 | GRIA2 (0.68) | GRIA2GRIA4ALDH1A1POLB | |
| SCHEMBL13611727 | 0.90 | GRIA2 (0.68) | GRIA2GRIA4 | |
| SCHEMBL8289561 | 0.86 | GRIA4 (0.65) | GRIA2GRIA4 | |
| SCHEMBL8289560 | 0.85 | GRIA4 (0.64) | GRIA2GRIA4 | |
| SCHEMBL13611798 | 0.84 | GRIA2 (0.65) | GRIA2GRIA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7625932-B2 | Pyrrole and pyrazole derivatives as potentiators of glutamate receptors | ELI LILLY AND COMPANY (US) | 2009-12-01 | — | — | US | disclosed |
| US-20070066573-A1 | Pyrrole and pyrazole derivatives as potentiators of glutamate receptors | ELI LILLY AND COMPANY | 2007-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070066573-A1 | Pyrrole and pyrazole derivatives as potentiators of glutamate receptors | GRIN1, GRIN3A, GRIK5 | GRIA2 17/4885GRIA4 16/4885ALDH1A1 2211/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.