SCHEMBL1361250

SCHEMBL1361250

O=[N+]([O-])c1ccc(-c2c(Cl)cc(C(F)(F)F)cc2C(F)(F)F)cc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.44
CYP3A4 P08684 1/20 0.44
HPGD P15428 1/20 0.44
ALOX15 P16050 1/20 0.44
TSHR P16473 1/20 0.44
HIF1A Q16665 1/20 0.44
TXNRD1 Q16881 1/20 0.44
TXNRD3 Q86VQ6 1/20 0.44
TXNRD2 Q9NNW7 1/20 0.44
TDP1 Q9NUW8 1/20 0.44
PSD A5PKW4 3/20 0.43
KIF11 P52732 1/20 0.42
AKR1C3 P42330 2/20 0.41
AKR1C2 P52895 2/20 0.41
MAPT P10636 1/20 0.41
RORC P51449 1/20 0.40
SCN2A Q99250 1/20 0.40
HSD17B10 Q99714 1/20 0.40
PTGS1 P23219 1/20 0.40
TRPV1 Q8NER1 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15858592 0.80 AKR1C3 (0.47) ALDH1A1PSDKIF11AKR1C3AKR1C2
SCHEMBL11428445 0.79 CYP1A2 (0.42) ALDH1A1CYP3A4HPGDALOX15TSHR
SCHEMBL28020021 0.75 AKR1C3 (0.59) ALDH1A1KIF11AKR1C3AKR1C2MAPT
SCHEMBL3480508 0.74 TDP1 (0.54) ALDH1A1CYP3A4HPGDALOX15TSHR
Water SCHEMBL11828402 0.73 HSD17B10 (0.52) ALDH1A1TSHRTDP1MAPTHSD17B10
SCHEMBL11072229 0.72 MAPT (0.49) ALDH1A1CYP3A4HPGDALOX15TSHR
SCHEMBL5430351 0.72 CA1 (0.55) ALDH1A1KIF11MAPTSCN2AABCC8
SCHEMBL11414692 0.72 PDE7A (0.43) ALDH1A1CYP3A4HPGDALOX15TSHR
SCHEMBL1830026 0.72 AKR1C3 (0.49) ALDH1A1KIF11AKR1C3AKR1C2MAPT
SCHEMBL1148427 0.72 HSD17B10 (0.60) ALDH1A1HPGDTDP1PSDMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8067638-B2 Amide derivative and insecticide containing the same MITSUI CHEMICALS, INC. (JP) 2011-11-29 US disclosed