SCHEMBL1361284

SCHEMBL1361284

C/C=C(/OC)O[Si](C)(C)C

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1361286 1.00
SCHEMBL3250928 1.00
SCHEMBL5110324 0.84
SCHEMBL10489206 0.82
SCHEMBL10358248 0.79
SCHEMBL8776762 0.78
SCHEMBL821097 0.78
SCHEMBL21457914 0.78
SCHEMBL11348176 0.78
SCHEMBL11348174 0.78

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5164499-A Nitroaryl carbonyl compounds, nitrodihydroaryl carbonyl intermediates thereto, and processes E. I. DU PONT DE NEMOURS AND COMPANY (US) 1992-11-17 US claimed
US-4912220-A Mixing a nitroaryl compound with an unsaturated silane under anhydrous conditions; adding a fluoride compound and an electrophilic compound E. I. DU PONT DE NEMOURS AND COMPANY (US) 1990-03-27 US claimed
US-4743690-A NITROARYL COMPOUND, SILANE, FLUORO ONIUM COMPOUND, BROMIDE E. I. DU PONT DE NEMOURS AND COMPANY (US) 1988-05-10 US claimed
US-4659862-A Process of preparing nitrodihydroaryl carbonyl compounds E. I. DU PONT DE NEMOURS AND COMPANY (US) 1987-04-21 US claimed
EP-3055300-B1 ANTAGONISTS OF PROSTAGLANDIN EP3 RECEPTOR PFIZER (US) 2018-03-07 EP disclosed
EP-3237401-A1 ANTAGONISTS OF PROSTAGLANDIN EP3 RECEPTOR Pfizer Inc (US) 2017-11-01 EP disclosed
US-9738626-B2 Antagonists of prostaglandin EP3 receptor PFIZER INC. (US) 2017-08-22 US disclosed
WO-2016103097-A1 ANTAGONISTS OF PROSTAGLANDIN EP3 RECEPTOR PFIZER INC. (US) 2016-06-30 WO disclosed
US-20160176851-A1 ANTAGONISTS OF PROSTAGLANDIN EP3 RECEPTOR PFIZER INC. (US) 2016-06-23 US disclosed
US-9278953-B2 Antagonists of prostaglandin EP3 receptor PFIZER INC. (US) 2016-03-08 US disclosed
US-20150099782-A1 ANTAGONISTS OF PROSTAGLANDIN EP3 RECEPTOR PFIZER INC. (US) 2015-04-09 US disclosed
EP-2094692-B1 MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1 AND/OR NF-KAPPAB ACTIVITY AND USE THEREOF BRISTOL MYERS SQUIBB CO (US) 2012-11-28 EP disclosed
US-5164499-A Nitroaryl carbonyl compounds, nitrodihydroaryl carbonyl intermediates thereto, and processes E. I. DU PONT DE NEMOURS AND COMPANY (US) 1992-11-17 US disclosed
US-4943648-A REACTION PRODUCT OF SILYL KETENE ACETAL AND UNSATURTED COMPOUND E. I. DU PONT DE NEMOURS AND COMPANY (US) 1990-07-24 US disclosed
US-4912220-A Mixing a nitroaryl compound with an unsaturated silane under anhydrous conditions; adding a fluoride compound and an electrophilic compound E. I. DU PONT DE NEMOURS AND COMPANY (US) 1990-03-27 US disclosed
US-4743690-A NITROARYL COMPOUND, SILANE, FLUORO ONIUM COMPOUND, BROMIDE E. I. DU PONT DE NEMOURS AND COMPANY (US) 1988-05-10 US disclosed
EP-0266062-A1 Group transfer polymerization catalyzed by mercury compounds E.I. DU PONT DE NEMOURS AND COMPANY (US) 1988-05-04 EP disclosed
US-4732955-A POLYMERIZING ACRYLIC MONOMER WITH ORGANOSILICON ACTIVAT OR E. I. DU PONT DE NEMOURS AND COMPANY (US) 1988-03-22 US disclosed
US-4659862-A Process of preparing nitrodihydroaryl carbonyl compounds E. I. DU PONT DE NEMOURS AND COMPANY (US) 1987-04-21 US disclosed
US-4448980-A BY CARBONYLATION WITH BIFLUORIDE CATALYSTS E. I. DU PONT DE NEMOURS AND COMPANY (US) 1984-05-15 US disclosed