Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRA | P16234 | 17/20 | 0.55 |
| ▸ | KDR | P35968 | 15/20 | 0.55 |
| ▸ | AXL | P30530 | 1/20 | 0.55 |
| ▸ | MET | P08581 | 2/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13613026 | 0.95 | PDGFRA (0.57) | PDGFRAKDRAXLMETHDAC1 | |
| SCHEMBL13613001 | 0.95 | PDGFRA (0.57) | PDGFRAKDRAXLMETHDAC1 | |
| SCHEMBL1894330 | 0.91 | AXL (0.67) | PDGFRAKDRAXLMETHDAC1 | |
| SCHEMBL13613028 | 0.89 | KDR (0.58) | PDGFRAKDRAXLMETHDAC1 | |
| SCHEMBL1896539 | 0.85 | AXL (0.69) | PDGFRAKDRAXLMET | |
| SCHEMBL1896142 | 0.84 | AXL (0.67) | PDGFRAKDRAXLMETHDAC1 | |
| SCHEMBL13613035 | 0.84 | KDR (0.59) | PDGFRAKDRAXLMETHDAC1 | |
| SCHEMBL5091900 | 0.84 | PDGFRA (0.72) | PDGFRAKDRAXL | |
| SCHEMBL13613025 | 0.83 | KDR (0.59) | PDGFRAKDRAXLMETHDAC1 | |
| SCHEMBL7476738 | 0.82 | PDGFRA (0.75) | PDGFRAKDRAXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612092-B2 | Urea derivatives containing aromatic or heteroaromatic rings; 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7-methoxy-6-quinolinecarboxamide; prophylactic or therapeutic agent for a disease for which angiogenesis inhibition is effective | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2009-11-03 | — | — | US | disclosed |