Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 12/20 | 0.68 |
| ▸ | PDGFRA | P16234 | 11/20 | 0.68 |
| ▸ | AXL | P30530 | 5/20 | 0.68 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.68 |
| ▸ | KIT | P10721 | 1/20 | 0.68 |
| ▸ | MET | P08581 | 3/20 | 0.57 |
| ▸ | AURKA | O14965 | 1/20 | 0.57 |
| ▸ | LCK | P06239 | 1/20 | 0.57 |
| ▸ | TEK | Q02763 | 1/20 | 0.57 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13613000 | 0.90 | PDGFRA (0.70) | KDRPDGFRAAXLFGFR2KIT | |
| SCHEMBL12501103 | 0.89 | KDR (0.66) | KDRPDGFRAAXLFGFR2KIT | |
| SCHEMBL13613020 | 0.88 | PDGFRA (0.68) | KDRPDGFRAAXLFGFR2KIT | |
| SCHEMBL1898773 | 0.88 | KDR (0.63) | KDRPDGFRAAXLFGFR2KIT | |
| SCHEMBL13613005 | 0.88 | KDR (0.67) | KDRPDGFRAAXLFGFR2KIT | |
| SCHEMBL5205758 | 0.85 | PDGFRA (0.76) | KDRPDGFRAAXLFGFR2KIT | |
| SCHEMBL5208548 | 0.85 | KDR (0.79) | KDRPDGFRAAXLFGFR2KIT | |
| SCHEMBL13613002 | 0.85 | KDR (0.63) | KDRPDGFRAAXLFGFR2KIT | |
| SCHEMBL5202303 | 0.84 | PDGFRA (0.73) | KDRPDGFRAAXLFGFR2KIT | |
| SCHEMBL5202090 | 0.83 | KDR (0.76) | KDRPDGFRAAXLFGFR2KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612092-B2 | Urea derivatives containing aromatic or heteroaromatic rings; 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7-methoxy-6-quinolinecarboxamide; prophylactic or therapeutic agent for a disease for which angiogenesis inhibition is effective | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2009-11-03 | — | — | US | disclosed |