Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 20/20 | 0.74 |
| ▸ | PDGFRA | P16234 | 18/20 | 0.71 |
| ▸ | KIT | P10721 | 2/20 | 0.64 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.64 |
| ▸ | AXL | P30530 | 1/20 | 0.64 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.62 |
| ▸ | STK10 | O94804 | 1/20 | 0.62 |
| ▸ | ABL1 | P00519 | 1/20 | 0.62 |
| ▸ | LCK | P06239 | 1/20 | 0.62 |
| ▸ | LYN | P07948 | 1/20 | 0.62 |
| ▸ | RET | P07949 | 1/20 | 0.62 |
| ▸ | MET | P08581 | 1/20 | 0.62 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.62 |
| ▸ | BCR | P11274 | 1/20 | 0.62 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.62 |
| ▸ | SRC | P12931 | 1/20 | 0.62 |
| ▸ | FLT1 | P17948 | 1/20 | 0.62 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.62 |
| ▸ | HTR2A | P28223 | 1/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6864391 | 0.89 | KDR (0.83) | KDRPDGFRAKITFGFR2AXL | |
| SCHEMBL14423796 | 0.88 | KDR (0.88) | KDRPDGFRAKITFGFR2AXL | |
| SCHEMBL5204147 | 0.88 | KDR (0.84) | KDRPDGFRAKITRIPK2STK10 | |
| SCHEMBL1895176 | 0.88 | KDR (0.72) | KDRPDGFRAKITFGFR2AXL | |
| Hydrochloric Acid SCHEMBL5202398 | 0.87 | KDR (0.82) | KDRPDGFRAKITRIPK2STK10 | |
| SCHEMBL13613029 | 0.87 | KDR (0.66) | KDRPDGFRAKITFGFR2AXL | |
| SCHEMBL5125963 | 0.86 | KDR (0.85) | KDRPDGFRAKITFGFR2AXL | |
| SCHEMBL1880429 | 0.85 | KDR (0.77) | KDRPDGFRAKITFGFR2AXL | |
| SCHEMBL5204741 | 0.85 | KDR (0.85) | KDRPDGFRAKITFGFR2AXL | |
| SCHEMBL13613040 | 0.85 | KDR (0.63) | KDRPDGFRAKITFGFR2AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612092-B2 | Urea derivatives containing aromatic or heteroaromatic rings; 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7-methoxy-6-quinolinecarboxamide; prophylactic or therapeutic agent for a disease for which angiogenesis inhibition is effective | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2009-11-03 | — | — | US | disclosed |